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EC number: 217-123-2 | CAS number: 1746-03-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1992-01-14 to 1992-02-07
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- 1981
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Version / remarks:
- 1984
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Vinylphosphonic acid
- EC Number:
- 217-123-2
- EC Name:
- Vinylphosphonic acid
- Cas Number:
- 1746-03-8
- Molecular formula:
- C2H5O3P
- IUPAC Name:
- vinylphosphonic acid
- Test material form:
- other: Liquid: Clear colourless
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: T 16/91
- Expiration date of the lot/batch: July 1992
- Purity test date: 1992-05-13
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: in the dark
- Stability under test conditions: stable
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: HOECHST AG, Kastengrund
- Age at study initiation: about 3-5 months
- Weight at study initiation: 2700-3600 g
- Housing: single
- Diet: Altromin 2123 Haltungsdiat - Kaninchen, Altromin-GmbH (Lage/Lippe, Germany), ad libitum
- Water: deionized, chlorinated water ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18+/- 3
- Humidity (%): 55+/- 20
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- physiological saline
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 500 mg
- Concentration: ca. 90 %
VEHICLE
- Amount applied: 0,05 mL NaCl (0,9 %) - Duration of treatment / exposure:
- 3 minutes and 4 hours
- Observation period:
- Observations were caried out 30-60 min and 24, 48, 72 h, 7 days and 14 days after removal of the test substance.
- Number of animals:
- 3 animals (3 min exposure)
1 animal (4 hours exposure) - Details on study design:
- TEST SITE
- Area of exposure: dorsal, about 2.5 x 2.5 cm
- Type of wrap if used: semiocclusive
REMOVAL OF TEST SUBSTANCE
- Washing: rinsing with tap water
- Time after start of exposure: 3 min or 4 h
OBSERVATION TIME POINTS
30-60min, 24 h, 48 h, 72 h, 7 days, 14 days
SCORING SYSTEM:
Erythema and edema were scored according to a 5 graded scale.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- 4 hours exposure
- Basis:
- animal #1
- Remarks:
- only one animal tested
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within:
- Remarks:
- 14 days
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- edema score
- Remarks:
- 4 hours exposure
- Basis:
- animal #1
- Remarks:
- only one animal tested
- Time point:
- 24/48/72 h
- Score:
- 1.3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 days
- Remarks on result:
- positive indication of irritation
- Irritation parameter:
- erythema score
- Remarks:
- 3 minutes exposure
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Remarks:
- 3 minutes exposure
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Remarks:
- 3 minutes exposure
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Remarks:
- 3 minutes exposure
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Remarks:
- 3 minutes exposure
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Remarks:
- 3 minutes exposure
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No signs of skin irritation were noticed after an exposure period of 3 minutes.
The animal exposed for 4 hours exhibited moderate to severe erythema at the observation time points 30-60 min, 24, 48, 72 h (score 3, respectively). At the observation time points 7 and 14 days the erythema were scored 4 (severe). Therefore, the findings were considered not reversible.
Edema were scored 3, 2, 1 and 1 at the time points 30-60 min, 24 h, 48 h and 72 hours and 1 after 7 and 14 days. - Other effects:
- - Other adverse local effects: The skin appeared discoloured/white after 4 hours exposure. Further effects observed throughout the observation period: encrustation, scaled and dry skin.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1C (corrosive) based on GHS criteria
- Conclusions:
- The test material was shown to be corrosive to skin after an exposure period of 4 hours.
- Executive summary:
The test material was examined for its potential to cause skin irritation/corrosion in New Zealand White rabbits. 500 mg were diluted with 0.05 mL 0.9 % NaCl and applied under semiocclusive dressing. Three animals were exposed for 3 minutes, one animal was exposed for 4 hours. After removal of the patches the test sites were washed with tap water. Skin findings were scored 30-60 min, 24 h, 48 h, 72 h and 7 and 14 days after removal. No skin findings were noted in the animals exposed for 3 minutes. Signs of moderate to severe irritation were observed in the animal exposed for 4 hours. These findings were not reversible within the 14 days-observation period. Therefore the test item was concluded to be corrosive to skin.
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