Registration Dossier
Registration Dossier
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EC number: 203-544-9 | CAS number: 108-03-2
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity study of 1-nitropropane in the rat
Acute dermal toxicity study in the rabbit.
Acute inhalation toxicity study in the rat.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 506 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 5 500 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
The oral LD50 was determined in rats to be 528 mg/kg/day for males and 484 mg/kg/day for females. The overall LD50 value for males and females was 506 mg/kg. Postmortem exams of animals dead after exposure showed distended and hemorrhagic intestines.
The dermal LD50 was determined in male and female rabbits to exceed 2000 mg/kg. No signs of toxicity were observed in these animals.
The acute inhalation toxicity, the LC50 was calculated from a rat LC50 at 1 hr (11.02 mg/L) by dividing by 2 as per the following guideline, "NFPA, Recommendations on the Transport of Dangerous Goods, UN Publication, 4th Ed. Section 6.4)." The calculated LC50 value of 5.5 mg/L was converted to 5500 mg/m3.
Justification for classification or non-classification
According to GHS classification for oral toxicity 1-nitropropane is a category 4 compound.
The calculated LC50 of 5500 mg/m3 indicates that 1-nitropropane is a category 3 compound.
No classification for Dermal toxicity is proposed based on the LD50 is excess of 2000 mg/kg bw.
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