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EC number: 241-677-4 | CAS number: 17689-77-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24.11.1999 to 02.05.2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to an appropriate OECD test guideline, and in compliance with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Triacetoxyethylsilane
- EC Number:
- 241-677-4
- EC Name:
- Triacetoxyethylsilane
- Cas Number:
- 17689-77-9
- Molecular formula:
- C8H14O6Si
- IUPAC Name:
- ethylsilanetriyl triacetate
- Details on test material:
- - Name of test material (as cited in study report): Ethyltriacetoxysilane
- Substance type: Si-carboxylate
- Physical state: Liquid
- Stability under test conditions: No data
- Storage condition of test material: Room temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River, New York
- Age at study initiation: 9-12 weeks
- Weight at study initiation: Males: 238-327 g; Females: 179-224 g
- Fasting period before study: Yes, overnight
- Housing: 2-6 per cage during acclimation and individually in suspended stainless steel cages with wire mesh bottoms.
- Diet (e.g. ad libitum): Ad libitum
- Water (e.g. ad libitum): Ad libitum
- Acclimation period: 7-16 days depending on the dose group.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-25
- Humidity (%): 20-66
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 30.11.1999 To: 06.01.2000
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: No data
- Doses:
- 300, 600, 1000, 1500 and 2000 mg/kg bw
- No. of animals per sex per dose:
- Five
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Clinical signs were noted at least once daily and body weights measured pre-test and weekly throughout the study.
- Necropsy of survivors performed: yes
- Other examinations performed: food consumption recorded daily and gross macroscopic examination.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 460 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1 270 - <= 1 680
- Mortality:
- See Table 1.
- Clinical signs:
- other: Signs observed in most groups on the day of dosing included red stains on the snout/extremities, lacrimation, excessive salivation and rales. Signs observed primarily in just the high dose groups (1000, 1500 and 2000 mg/kg bw) included yellow ano-genital
- Gross pathology:
- Findings in the stomach were distention and abnormal content, various discolorations, increased thickness of the gastric wall and, in a small number of rats, sores/depressions in the gastric mucosa. In the peritoneal/abdominal cavity, the test substance-related findings were adhesions between the stomach and other abdominal organs and the presence of abnormal peritoneal content. Overall, the findings in the stomach and in the peritoneal cavity were most prominent at 2000 mg/kg bw followed by the 1500 mg/kg bw group. Discoloration of the stomach occurred in 1/5 males and 1/5 females in the 300 mg/kg bw group. In the 1000 mg/kg bw group, increased thickness of the gastric wall occurred in 1/5 females and peritoneal adhesions occurred in 1/5 males. Other macroscopic findings occurred sporadically in the 300, 600, 1500 and 2000 mg/kg bw groups; these findings were not considered to be related to the test substance.
- Other findings:
- None
Any other information on results incl. tables
Table 1: Mortality results
Dose |
Mortality (# dead/total) |
Time of deaths |
||
Male |
Female |
Combined |
||
300a |
0/5 |
1/5b |
1/10 |
Day 3 |
600a |
0/5 |
0/5 |
0/10 |
N/A |
1000 |
0/5 |
0/5 |
0/10 |
N/A |
1500 |
3/5 |
3/5 |
6/10 |
1, 21 hours, Day 3, 5 and 8 |
2000 |
4/5 |
4/5 |
8/10 |
22 hours, Day 2, 3, 4, 8 and 10 |
a Dose levels excluded from LD50 calculation.
b The cause of death of this animal was due to a dosing error.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In an oral gavage study conducted to the now deleted OECD 401 and to GLP (reliability score 1) the LD50 for triacetoxyethylsilane was 1460 mg/kg bw in rats. Clinical signs and macroscopic findings appeared to be related to the corrosive properties of the test substance on the stomach.
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