Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 942-381-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study in compliance with GLP-criteria.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 72008-25-4
- EC Number:
- 615-703-3
- Cas Number:
- 72008-25-4
- IUPAC Name:
- 72008-25-4
- Details on test material:
- - Name of test material (as cited in study report): Asta-C6-Acetal (CG-Acl)
- Physical state: fluid
- Stability under test conditions: Not stable against acids/caustic solutions
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- At the start of the test (after 0 hours) samples from vessels which were not stocked with daphnids were analysed and at the end of the test (after 48 h) samples from stocked and unstocked vessels were analysed.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- At the beginning of the test and after 24h the stock solution of the test substance was freshly prepared. A defined amount of the substance was weighed out and suspended directly in the test medium by stirring (about 30 min at 20°C). The nominal concentration of the stock solution was 100 mg/L. By dilution of this stock solution with test medium the following nominal concentrations were prepared.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
The clone of Daphnia magna STRAUS used was supplied by Institut National de Recherche Chimique Applique France, in 1978. The daphnids are cultured under standard conditions in the laboratory.
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- 2.2 - 3.2 mmol/L
- Test temperature:
- 20.2 - 21.3 °C
- pH:
- 7.9 - 8.2
- Dissolved oxygen:
- 7.9 - 8.5 mg/L
- Nominal and measured concentrations:
- Nominal concentrations:
0; 12.5, 25, 50, 100 mg/L
Measured concentrations (recoveries):
t=0: 89.3-92.7%
t=24h: 53.2-57.7%
t=24h (stocked): 43.8-48.8% - Details on test conditions:
- TEST SYSTEM
- Test vessel: 20-mL open flat bottom glass tubes
- Test volume: 10 mL
- Aeration: no
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
- Loading: 0.5 animals per mL
TEST MEDIUM / WATER PARAMETERS
- Culture medium: synthetic medium M4 as defined in Guideline C.2 is used for the culture and test. The medium is prepared on the basis of on ultrapure, deionized water (conductivity < 0.05 pS/cm).
- Source/preparation of dilution water: according to the test guideline DIN 38412, L 11:
- Ca/mg ratio: 4:1
OTHER TEST CONDITIONS
- Adjustment of pH: yes for two additional concentrations which were tested in parallel (50 and 100 mg/L)
- Photoperiod: 16 : 8 hours day-night regime
- Light intensity: diffuse light (5 µE/m²·s) at 400 - 750 nm wave length
EFFECT PARAMETERS MEASURED
- Test parameter: swimming ability of the test animals, visually after 0, 3, 6, 24 and 48 h. - Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 71.9 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks:
- lowest measured value corresponding to effect
- Details on results:
- Only at the highest two test concencentrations was 5% immobility noted after 48 hours exposure.
The low recovery rates after 24 h of 43.5 to 57.7 % are reported to be caused by degradation of the test substance. - Reported statistics and error estimates:
- Due to the results of the test a statistical evaluation of the data was unnecessary.
Any other information on results incl. tables
Immobilisation
Nominal conc. (mg/l) |
Cumulative immobilisation (n) |
|||
3 h |
6 h |
24 h |
48 h |
|
12.5 |
0 |
0 |
0 |
0 |
25 |
0 |
0 |
0 |
0 |
50 |
0 |
0 |
0 |
1 |
100 |
0 |
0 |
0 |
1 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.