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EC number: 443-510-2 | CAS number: 738587-10-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Study test phase 2002-10-22 to 2002-10-25. Report sign off 2002-11-14
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Meets the criteria for classification as Reliable without restriction according to Klimisch et al (1997)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC estimation method
- Media:
- other: HPLC
Test material
- Reference substance name:
- -
- EC Number:
- 443-510-2
- EC Name:
- -
- Cas Number:
- 738587-10-5
- Molecular formula:
- C26H14N10Ni2O18S4 as free acid
- IUPAC Name:
- dinickel(2+) sodium 3-carboxy-5-[(1E)-2-(7-oxido-2,6-disulfonaphthalen-1-yl)diazen-1-yl]-1H-1,2,4-triazol-1-ide 3-carboxy-5-[(1E)-2-(7-oxido-2-sulfo-6-sulfonatonaphthalen-1-yl)diazen-1-yl]-1H-1,2,4-triazol-1-ide
Constituent 1
- Radiolabelling:
- no
Study design
- Test temperature:
- 20.1 - 22.3 deg C
HPLC method
- Details on study design: HPLC method:
- EQUIPMENT
- Apparatus: A HPLC system comprising of the following components - HPLC pump, 25cm x 4.6mm id column packed with a 5um CN phase, Photo Diode Array (PDA) detector, Chromotography data system.
- Injection volume: 100ul
MOBILE PHASES
- Type: 55% methanol and 45% pH adjusted deionised water pumped at a flow rate of 1.5 ml/min
DETERMINATION OF DEAD TIME
- Method: by inert substances which are not retained by the column (sodium nitrate)
REFERENCE SUBSTANCES
- Identity: Acetamilide, Atrazin, Isoproturon, Linuron, Naphthalene, 1,2,3-Trichlorobenzene, Fenthion, Phenanthrene, ppDDT.
DETERMINATION OF RETENTION TIMES
- Quantity of test substance introduced in the column:100ul
- Quantity of reference substances:100ul
REPETITIONS
- Number of determinations: Reference substances were injected in duplicate as a minimum and average retention times determined. This was performed as least once daily.
EVALUATION
- Calculation of capacity factors k': k' = (retention time of test substance - column dead time)/ column dead time
- Calculation of retention times: measured by HPLC
- Determination of the log Koc value: Determined from equation of the line from the calibration graph of logKoc versus logk'
Batch equilibrium or other method
- Analytical monitoring:
- no
Results and discussion
Adsorption coefficientopen allclose all
- Type:
- log Koc
- Remarks:
- Estimated
- Value:
- > 5
- Remarks on result:
- other: pH2
- Type:
- log Koc
- Remarks:
- Estimated
- Value:
- > 5
- Remarks on result:
- other: pH10
Results: HPLC method
- Details on results (HPLC method):
- - Retention times (s) of reference substances used for calibration:
pH2
Sodium nitrate 91 (this is the t0 value)
Acetamilide 137
Atrazin 147
Isoproturon 158
Linuron 162
Naphthalene 183
1,2,3-Trichlorobenzene 174
Fenthion 190
Phenanthrene 232
pH10
Sodium nitrate 83 (this is the t0 value)
Acetamilide 135
Atrazin 138
Isoproturon 153
Linuron 156
Naphthalene 175
1,2,3-Trichlorobenzene 167
Fenthion 180
Phenanthrene 218
- Details of fitted regression line (log k' vs. log Koc): pH2 y = 5.857x + 3.018 r2 = 0.928, pH10 y=7.704x + 2.844 r2=0.932
- Average retention data (s) for test substance: pH2 >900, pH10 71
Any other information on results incl. tables
At pH 2 the log Koc is >5.0 and at pH 10 the log Koc is <1.5.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test method has been validated for the quantitative estimation of logKoc values in the range 1.5 to 5.0. In those instances where the statistical treatment of the experimental data produces a calculated log Koc value outside of this range then the final result is quoted as either <1.5 or >5.0 as appropriate. At pH 2 the logk' for the test substance was >0.949 therefore the estimated logKoc for the test substance is >5.0. At pH 10 it was not possible to calculate the logk' for the test substance therefore the estimated log Koc for the test substance is <1.5.
- Executive summary:
Introduction
This study was undertaken to determine the adsorption coeffiecient (Koc) of the test substance using a high peformance liquid chromatography (HPLC) correlation technique. The method was designed to be compatible with the following
- OECD Guideline for the Tesing of Chemicals (2001).Test Guideline 121, Estimation of the Adsorption Coefficient (Koc) on Soil and Sewage Sludge using High Performanec Liquid Chromatography (HPLC). (22 January 2001).
Results & Conclusions
At pH 2 the logk' for the test substance was >0.949 therefore the estimated logKoc for the test substance is >5.0. At pH 10 it was not possible to calculate the logk' for the test substance therefore the estimated log Koc for the test substance is <1.5.
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