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EC number: 469-300-0 | CAS number: 63675-73-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Jun 2006 to Oct 2006
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 469-300-0
- EC Name:
- -
- Cas Number:
- 63675-73-0
- Molecular formula:
- Hill Empirical Formula: C16H16O3S CAS Empirical Formula: C16H16O3S
- IUPAC Name:
- 1-(4-methoxyphenyl)-2-[(3-methoxyphenyl)sulfanyl]ethan-1-one
- Test material form:
- solid: particulate/powder
- Details on test material:
- Lot no: 151105Purity - 101.39%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: HsdRccHan:WIST strain (nulliparous, non-pregnant)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Male and female (nulliparous, non-pregnant) rats of the HsdRccHan:WIST strain were obtained from Harlan UK Lld, Bicester. All animals were given a clinical inspection for ill health on arrival and a sample was weighed.Preliminary testThe Study Director selected a dosing regimen that was intended either to demonstrate that the maximum dose level was unlikely to be lethal in the main study, or to determine a broad range of d ose levels that included the acute median lethal dose. The maximum dose level did not exceed 2000 mg/kg; the "limit test" dose level specified in the test guidelines. A pair of animals (one male and one female) received a single dermal dose of test article at 2000 mg/kg.Main study - limit testSince no compound-related mortality occurred in the preliminary test, one group of five male and five female rats was subjected to single dermal application of the test article at 2000 mg/kg. This group consisted of the two animals used in the preliminary test plus a further four male and four female rats to give the required group size of five males and five females.
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- water
- Details on dermal exposure:
- The test article was applied as a moistened powder to the clipped dorsum of a group of five male and five female rats on Day 1. Each rat received a single topical application at a dose level of 2000 mg/kg. The treated areas of dorsum were covered by a semi-occlusive dressing for 24 hours. All animals were killed on Day 15 and subsequently underwent a full necropsy.
- Duration of exposure:
- 24 h
- Doses:
- 2000mg/kg
- No. of animals per sex per dose:
- 5 males, 5 females
- Control animals:
- no
- Details on study design:
- Male and female (nulliparous, non-pregnant) rats of the HsdRccHan:WIST strain were obtained from Harlan UK Lld, Bicester. All animals were given a clinical inspection for ill health on arrival and a sample was weighed.
Results and discussion
- Preliminary study:
- The Study Director selected a dosing regimen that was intended either to demonstrate that the maximum dose level was unlikely to be lethal in the main study, or to determine a broad range of dose levels that included the acute median lethal dose. The maximum dose level did not exceed 2000 mg/kg; the "limit test" dose level specified in the test guidelines. A pair of animals (one male and one female) received a single dermal dose of test article at 2000 mg/kg.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
- Clinical signs:
- other: Signs of toxicity related to dose levels: No clinical signs of reaction to treatment.
- Gross pathology:
- Effects on organs: None
- Other findings:
- Signs of toxicity (local):No clinical signs of reaction to treatment.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute median lethal dermal dose or Beta Ketosulfide to rats was found to exceed 2000 mg/kg.The test material was considered to have no significant acute toxic risk in respect or its acute dermal toxicity and did not meet the criteria for classification according to EU labelling regulations Commission Regulation (EC) 1272/2008.
- Executive summary:
This study was conducted to assess the acute dermal toxicity of the test article, BetaKetosulfide following a single (24hour) semi-occluded topical application to the rat.
The test article was applied as a moistened powder to the clipped dorsum of a group of five male and five female rats on Day1. Each rat received a single topical application at a dose level of 2000 mg/kg. The treated are as of dorsum were covered by a semi-occlusive dressing for 24 hours. All animals were killed on Day 15 and subsequently underwent a full necropsy.
No animal died and there were no clinica lsigns of reaction to treatment.No overt dermal changes were noted at the test site following a single application at 2000mg/kg. All rats achieved bodyweight gains during the study period. Macroscopic changes noted during necropsy of rat skilled on Day 15 were confined to a red area on the test site in one male and red foci on the lungs of one other male.However, it was considered that these were unlikely to be treatment related.
The acute median lethal dermal dose of Beta Ketosulfide to rats was found to exceed 2000mg/kg. The test material was considered to have no significant acute toxic risk in respect of its acute dermal toxicity and did not meet the criteria forclassification according to EU labelling regulations Commission Regulation (EC) 1272/2008.
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