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EC number: 402-140-1 | CAS number: 17865-32-6 CHMMS; CHMS; DYNASYLAN 9407; Z-6187
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
There are no in vivo data on the toxicokinetics of cyclohexyl(dimethoxy)methylsilane.
The only in vitro data are for dermal absorption. The following summary has therefore been prepared mainly based on validated predictions of the physicochemical properties of the substance itself and its silanol hydrolysis product. Cyclohexyldimethoxymethylsilane is a moisture-sensitive liquid that hydrolyses in contact with water (half-life 19 hours at pH 7, read-across from dicyclopentyldimethoxysilane), generating methanol and cyclohexyldimethoxymethylsilane. Human exposure can occur via the inhalation or dermal routes. Relevant inhalation exposure would be to the parent substance.
Absorption
Oral: Significant oral exposure is not expected for this substance.
Dermal: In an in vitro dermal absorption study conducted according to OECD Test Guideline 428 and in compliance with GLP (BSL Bioservice, 2006) the dermal absorption of cyclohexyl(dimethoxy)methylsilane was less than 0.2% of the applied dose over 12 hours.
Inhalation: The predicted water solubility (151 mg/l) and log Kow(4.25) of the parent substance are favourable for absorption from the respiratory tract epithelium by micellar solubilisation. However, the high-water solubility of the hydrolysis product, cyclohexylmethylsilanediol (32,000 mg/l) might lead to some of this hydrolysis product being retained in the mucus of the lungs. Therefore, once hydrolysis has occurred, absorption may slow down. There were no signs of systemic toxicity in the key acute inhalation toxicity study, and therefore no evidence of absorption.
Distribution
The parent substance is lipophilic, is likely to distribute into cells and the intracellular concentration might be higher than the extracellular concentration, particularly in fatty tissues. The hydrolysis product is not likely to be as widely distributed due to its high-water solubility.
Metabolism
There are no data regarding the metabolism of cyclohexyl(dimethoxy)methylsilane or its hydrolysis product. Genetic toxicity tests in vitro showed no observable differences in effects with and without metabolic activation for cyclohexyl(dimethoxy)methylsilane.
Excretion
The low molecular weight and high-water solubility of the hydrolysis product, cyclohexyl(dimethoxy)methylsilane, suggest that it is likely to be effectively eliminated via the kidneys in urine. The parent substance however, is predicted to be highly lipophilic and therefore not as readily eliminated from the body.
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