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Diss Factsheets
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EC number: 203-472-8 | CAS number: 107-20-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Only female rats have been used. Preliminary trials showed that there are no sex-related differences.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Principles of method if other than guideline:
In principle according to OECD 402.
Deviation: Only females were used. Preliminary trials had shown that there is no sex-related difference.- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Chloroacetaldehyde
- EC Number:
- 203-472-8
- EC Name:
- Chloroacetaldehyde
- Cas Number:
- 107-20-0
- Molecular formula:
- C2H3ClO
- IUPAC Name:
- 2-chloroacetaldehyde
- Test material form:
- other: 45 % solution
- Details on test material:
- 45 % aqueous solution of Monochloracetaldehyde
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Source: SPF-Wistar-rats
- Weight at study initiation: 155-197 g
- Fasting period before study: 16 hours
- Housing: synthetic material cages, shavings
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Hairless and intact skin on the back, approx. 30 cm2 treated with the undiluted test substance. Occlusive (aluminium foil fixed with Elastoplast 8 cm from Beiersdorf AG, Hamburg).
- Duration of exposure:
- 24 h
- Doses:
- 50, 100, 160, 200, 1250, 5000 mg/kg KG
- No. of animals per sex per dose:
- 6 female rats per dose
- Control animals:
- no
- Details on study design:
- After 24 h the dressing was removed and the test substnace removed with warm water. The animals were examined once daily (not on the weeksend) for 14 days. All surving animals were sacrificed after the observation period and subject to macroscopic examination.
- Statistics:
- The LD50 calculation was done by probit analysis according to Lindner & Weber. Results: LD50
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 140 mg/kg bw
- Based on:
- test mat.
- Mortality:
- LD50 = 140 mg/kg body weight. Mortality occured within 60 minutes up to 7 days p.a..
- Clinical signs:
Symptoms:
Crying, restlessness, restless behaviour followed
by decreased activity, closed eyes, tremor, ataxia, gasping
dispneua, general bad health condition.
The treated skin areas showed erythema, swelling, yellow discoloration,
indurcisment, necrosis.- Body weight:
- no data
- Gross pathology:
- The macroscopic examination at autopsy of the dead animals
showed heavy erythema and oedema of the subcutis as well as
reddish discoloration of the mucosa of stomach and intestines.
Stomach and intestines were partially filled with red up to
black content.
The macroscopic examination of the survivors, killed after
14 days, did not show visible alternations. - Other findings:
- none
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- LD50 = 140 mg/kg body weight. Mortality occured within 60 minutes up to 7 days p.a.
- Executive summary:
From the mortality figures the acute dermal toxicity of a 45 % aqueous solution of Monochloracetaldehyde in female rats was calculated to be 140 mg/kg.
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