Registration Dossier
Registration Dossier
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EC number: 940-643-2 | CAS number: -
Eye irritation
Administrative data
- Endpoint:
- eye irritation
- Remarks:
- other: Category approach based on OECD-405 tests in the APP category.
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Category is coherent for more than 10 endpoints. If skin irritation occured it would be related to the properties of surfactant and 2 substances in the category do not exhibit any skin irritation effect.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
Materials and methods
- Principles of method if other than guideline:
- Guidance on information requirements and chemical safety assessment - Chapter R.6: QSARs and grouping of chemicals - May 2008
- GLP compliance:
- no
- Remarks:
- Not relevant for category approach.
Test material
- Reference substance name:
- D-pentose, oligomeric, C14 and C18 alkyl glycosides
- EC Number:
- 940-643-2
- IUPAC Name:
- D-pentose, oligomeric, C14 and C18 alkyl glycosides
Constituent 1
Results and discussion
In vivo
Results
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 1, 24, 48, 72 hours
- Score:
- >= 0 - <= 0.7
- Max. score:
- 1
- Reversibility:
- fully reversible
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- According to OECD-405 test when APP-6669 was applied on rabbit eye, only a slight effect was observed in one animal and disappeared after 1 day. A read across from this substance and the category context allow to conclude that no classification for eye irritation is needed (see detailed discussion in APP category report).
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