Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 610-915-2 | CAS number: 52937-90-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
Category Approach for three different 3-aminocrotonic acid esters
Testsystem |
- (CAS-No. 14205-39-1) |
- Isopropylester (CAS-No. 14205-46-0) |
- Isobutylester (CAS-No. 52937-90-3) |
Akut oral |
Classification with R 22/ Acute Tox 4 LD50:1760 mg/kg Results: 1300 mg without findings, ≥1500 narcosis, cyanosis, etc.; irritation in the stomach mucosa (Bayer internal report: Löser, 1983-06-30, T2015646) |
No classification LD50: > 2000 mg/kg Results: limit dose study; piloerection and diuresis up to 48 h after dosing (Bayer internal report: Bomhard, 1989-03-01, No. 17779) |
Classification with R 22 / Acute Tox 4 LD50:1400 mg/kg Results: 1000 mg without findings, ≥1300 mortality; narcosis, cyanosis, etc. irritation in the stomach mucosa (Bayer internal report: Ramm, 1985-11-12, No. T0020251) |
Akut inh. |
LC50 > 23 mg/m³ (dust; maximal technically feasible concentration) (Bayer internal report: Pauluhn, 1983-04-27, No. 11752) |
>6064 mg/m³ (aerosol) (Bayer internal report: Pauluhn, 1989-06-20, No. 18104) |
No data |
Skin irritation |
No classification Bayer report: Slight skin irritation (erythema grade 2, 24h; grade 1, 48h) Lonza report: No skin irritation (Bayer internal report: Schmidt, 1983-08-04, T5045748) |
No classification Slight skin irritation (erythema 0.3-1.0) (Bayer internal report: Märtins, 1989-03-20, No. 17843) |
No classification No data available Slight irritation expeced via category approach
|
Eye irritation |
Classification with R 41/ Eye Damage 1 Bayer report: Slight irritation (mean: cornea 0.3-0.7; erythema 1.3-2.0; chemosis 1.3-2.3) Lonza report: 1 animal with cornea grade 2 not reversible; animal 2 and 3: slight (Bayer internal report: Schmidt, 1983-08-03, T6015767) (Lonza report: Donald, 2000-03-23, No. 3202) |
Classification with R 36 / Eye Damage 2 Cornea grade 1-2, erythema grade 1-2, reversible (Bayer internal report: Märtins, 1989-03-20, No. 17843) |
Classification with R 36 / Eye Damage 2 No data available Eye irritation expeced via category aproach
|
Skin sensi |
Classification with R 43 / Skin sens 1 B Bayer report: M&K neg (paraffin; 5%, 12%, 1%; 1.challenge 3/10, 2. 1/10) Lonza report: M&K positive (maize oil, induction max. practicable conc.; challenge: max non-irritant conc. ; 4%, 60%, 60%; 10/10); QSAR toolbox predicts moderate skin sensitization potential (via Michael addition) (Bayer internal report: Stropp, 1997-08-07, No. 26525) (Lonza report: Donald, 2000-03-23, No. 3204) |
Classification with R 43/ Skin sens 1 B No animal data available QSAR toolbox predicts moderate skin sensitization potential (via Michael addition) Moderate skin sensitizing potential expected via category approach and QSAR
|
Classification with R 43 / Skin sens 1 B No animal data available QSAR toolbox predicts moderate skin sensitization potential (via Michael addition) Moderate skin sensitizing potential expected via category approach and QSAR
|
Ames Test (4 Salmonella strains) |
No classification Negativ (Bayer internal report: Herbold, 1986-01-07, No. 14189) |
No classification Negativ (Bayer internal report: Herbold, 1990-08-08, No. 19390 plus Amendment of 1994) |
No classification Negativ (Bayer internal report: Herbold, 1986-04-01, No. 14493) |
In vivo mouse bone marrow MNT |
No data |
Negativ (Bayer internal report: Herbold, 1990-05-29, No. 19096 plus Amendment of 1994) |
No data |
Justification for classification or non-classification
Based on a category approach with three different 3 -aminocrotonic acid esters, for 3 -aminocrotonic acid butyl ester a classification regarding skin irritation is not warranted.
Based on the above mentioned category approach, 3 -aminocrotonic acid butyl ester should be classified according to EU Regulation 1272/EEC with Eye Damage Category 2 (H319) and according to 67/548/EEC with R 36 (irritating to eyes).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.