Registration Dossier
Registration Dossier
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EC number: 609-736-2 | CAS number: 39672-75-8
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
The substance is an intermediate of a corticosteroid; it may be teratogenic and embryocidal in rabbits and rats.
Read-across from supporting substance Budesonide (CAS 51333-22-3)
Toxicity to reproduction: other studies
Additional information
Budesonide was teratogenic and embryocidal in rabbits and rats. Budesonide produced fetal loss, decreased pup weights, and skeletal abnormalities at subcutaneous doses of 25 mcg/kg in rabbits (approximately 0.05 times the maximum recommended human dose on a body surface area basis) and 500 mcg/kg in rats (approximately 0.5 times the maximum recommended human dose on a body surface area basis).
Justification for classification or non-classification
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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