Registration Dossier
Registration Dossier
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EC number: 601-577-7 | CAS number: 118969-29-2
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 3-[(2E)-2-benzylidenehydrazino]-4-sulfonatobenzoate, disodium salt
- EC Number:
- 601-577-7
- Cas Number:
- 118969-29-2
- Molecular formula:
- C14H10N2Na2O5S
- IUPAC Name:
- 3-[(2E)-2-benzylidenehydrazino]-4-sulfonatobenzoate, disodium salt
- Details on test material:
- Purity 59.2%
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- other: S. typhimurium TA 1535, TA 1537, TA 1538, TA 98 and TA 100
- Test concentrations with justification for top dose:
- Range in the cytotoxicity test
20.6 - 5000 µg/plate
Range in the orig. mutagenicity test
61.7 - 5000 µg/plate
Range in the conf. mutagenicity test
104.3 - 8446 µg/plate
Results and discussion
Any other information on results incl. tables
In the confirmatory experiment performed without and with metabolic activation, the tested concentrations of tested substance did not lead to an increase in the incidence of histidine-prototrophic mutants by comparison with the negative control.
Applicant's summary and conclusion
- Conclusions:
- The test substance exerted no toxic effect on the growth of the bacteria.
- Executive summary:
The test substance exerted no toxic effect on the growth of the bacteria.
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