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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
carcinogenicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
before 1999
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data given. Study meets generally accepted scientific principles. Study acceptable for assessment
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
1999

Materials and methods

GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
1,3-propanesultone
EC Number:
214-317-9
EC Name:
1,3-propanesultone
Cas Number:
1120-71-4
Molecular formula:
C3H6O3S
IUPAC Name:
1,2-oxathiolane 2,2-dioxide
Details on test material:
1,3-Propane sultone (purity 91%)

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
26 animals per group

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
32 or 60 weeks
Frequency of treatment:
twice a week
Post exposure period:
post-treatment observation period up to 60 weeks
Doses / concentrations
Remarks:
Doses / Concentrations:
28 or 56 mg/kg bw per day
Basis:
nominal conc.
No. of animals per sex per dose:
26
Control animals:
other: Two groups (matched and pooled): 1 of 16 males and 16 females and 1 of 26 males and 26 females, respectively
Positive control:
no

Results and discussion

Results of examinations

Clinical signs:
effects observed, treatment-related
Description (incidence and severity):
28 mg/kg bw group 52 w survival male 62%, female 39%. 56 mg/kg bw group 52 w survival male 15%, female 23%.
Mortality:
mortality observed, treatment-related
Description (incidence):
28 mg/kg bw group 52 w survival male 62%, female 39%. 56 mg/kg bw group 52 w survival male 15%, female 23%.
Histopathological findings: neoplastic:
effects observed, treatment-related
Description (incidence and severity):
cerebral and other tumors elevated by a factor of approx. 10
Relevance of carcinogenic effects / potential:
According to the American Conference of Governmental Industrial Hygienists (ACGIH) the substance is a confirmed animal carcinogen with unknown relevance to humans

Any other information on results incl. tables

Administration of the high dose stopped at w 32 because of high mortality and numerous mammary tumours

Applicant's summary and conclusion

Conclusions:
Carcinogenous
Executive summary:

The substance is a confirmed animal carcinogen with unknown relevance to humans