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EC number: 202-860-4 | CAS number: 100-52-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: No guideline followed. Non-GLP. Only secondary source. Only short notice.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- Klecak, G. et al., J., cited in German MAK documentation 1998
- Year:
- 1 977
- Bibliographic source:
- J. Soc. Cosmet. Chem. 28, 53-64 (1977)
Materials and methods
- Principles of method if other than guideline:
- Methods specified as Draize test (DT), Mazimization Test (MT) and Intradermal Test with Freund's complete adjuvant (FCAT).
- GLP compliance:
- not specified
- Type of study:
- other: Maximization test
Test material
- Reference substance name:
- Benzaldehyde
- EC Number:
- 202-860-4
- EC Name:
- Benzaldehyde
- Cas Number:
- 100-52-7
- Molecular formula:
- C7H6O
- IUPAC Name:
- benzaldehyde
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
Results and discussion
Any other information on results incl. tables
Positive, but incompletely documented results were obtained in a study with benzaldehyde in the Draize Test, maximization test and FCA test with male and female guinea pigs (Himalayan white-spotted). In the Draize Test the animals were treated once intradermally with 0.05 mL and on nine subsequent days with 0.1 mL of a 0.1% preparation of benzaldehyde (in total 0.95 mg/animal) in isotonic saline. Provocation was carried out on days 35 and 49 by intradermal injection of 0.05 mL of the 0.1 % preparation. The test protocol of the maximization test corresponded more or less with the standard conditions: intradermal induction with 5 % benzaldehyde (in total 20 mg, vehicle not specified), epicutaneous induction by means of 48 -hour occlusive treatment with a moderately irritative preparationof 25 % benzaldehyde (250 mg) in petroleum, provocation on day 21 with a non-irritative concentration in petrolatum (24 h, occlusive, no further details).In the FCA test, induction was carried out by 5 injections in the necks of the animals on days 0, 2, 4, 7 and 9 of 0.05 mL (in total about 250 mg) ofthe undiluted substance spiked with the same amount of FCA, and provocation on days 21 and 35 with a non-irritative concentration in petrolatum (24 h,occlusive, no further details). Control animals were treated intradermally with FCA only (Klecak et al., 1977). In summary, the reported test result was negative for the Open Epicutaneous Test (OT) and positive for the Draize Test, Mazimization Test and Intradermal Test with Freund's complete adjuvant. Thus, a skin sensitizing potential can be presumed, based on theat information.
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information
- Conclusions:
- Based on the results of the above cited study, and due to the presence of a structural alert for protein binding (aldehyde group), a skin sensitization potential of benzaldehyde appears likely. Thus, benzaldehyde is classified skin sens. Cat.1 and R43 according to Regulation (EU) 1272/2008 and EU Directive 67/548/EEC, respectively.
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