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EC number: 273-761-1 | CAS number: 69012-64-2 Amorphous silicon dioxide particles from the volatilization and vaporization of furnace feed materials in the manufacture of ferrosilicon and silicon.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: A scientific review by authorative international body
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- SIDS initial assessment report for SIAM 19. Synthetic amorphous silica and silicates.
- Author:
- OECD
- Year:
- 2 004
- Bibliographic source:
- UNEP Publications, Berlin.
Materials and methods
- Principles of method if other than guideline:
- OECD evaluated the available test data on synthetic amorphous silica.
- GLP compliance:
- no
- Remarks:
- review - both yes and no status
- Test type:
- other: different acute oral toxicity tests
Test material
- Reference substance name:
- 112926-00-8; 112945-52-5
- IUPAC Name:
- 112926-00-8; 112945-52-5
- Details on test material:
- Tradenames studied in OECD (2004): Aerosil 200; Sident 9; Sipernat 22; Syloid 244; Tixosil 53; Aerosil 130, 150, 200, 300, OX50, Ultrasil VN 2 and 3, silika FK types, Sident 3, Sipernat AS 7, 22, 30 and 42; ZEO 49, ZEOSYL 113, ZEOSYL 200, ZEOFREE 153; Positive Sol 130M; Cab-O-Sil M-5 and F-2
Constituent 1
Test animals
- Species:
- other: rat and mouse
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 110 mg/kg bw
- Remarks on result:
- other: hydrophilic precipitated silica
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Remarks on result:
- other: hydrophilic precipitated silica
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Remarks on result:
- other: several silica types
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- > 20 000 mg/kg bw
- Remarks on result:
- other: hydrophilic precipitated silica
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 3 160 mg/kg bw
- Remarks on result:
- other: hydrophilic pyrogenic silica
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- OECD (2004) includes 12 acute oral toxicity studies with synthetic amorphous silica, of which five is regarded as critical study for SIDS endpoint. These five studies are conducted with hydrophilic precipitated or pyrogenic silica. In the critical studies, the LD50 or LDO value was at least >3160 mg/kg bw, thus showing no acute oral toxicity.
- Executive summary:
In OECD (2004), the acute oral administration of hydrophilic precipitated or pyrogenic silica either by gavage or in the diet
failed to produce signs of toxicity or deaths in treated animals with LD50values greater than the top doses applied. Thus, the LD50values varied from >3100 to >20000 mg/kg bw. In conclusion, acute oral ingestion to high doses of synthetic amorphous silica will produce no systemic toxicity.
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