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EC number: 213-697-3 | CAS number: 1003-03-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In a skin irritation study, the test item was found to be a skin corrosive. In addition, it was also classified a severely eye damaging.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No GLP study no OECD and EU guidelines were followed.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- Method: according to Federal Register Volume 37, No. 244, December, 1972 (intactand abraded skin, 4h, occlusive)
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Nottingham University, School of Agriculture, Sutton Bonington, Nr . Loughborough, Leicestershire
- Weight at study initiation: 2 .0 - 3 .0 kg
- Housing: Animals were housed individually in suspended metal cages.
- Diet: ad libitum, Rabbit Diet, supplied by John Waring Limited, Shardlow, Derbyshire
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 + 3°C
- Air changes (per hr): 20 air changes per hour
- Photoperiod (hrs dark / hrs light): 14 hours light, 10 hours dark - Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.5 mL - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 4, 24 and 48 hours
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: 50 mm x 50 mm
- Type of wrap if used: a composite patch
SCORING SYSTEM: according to Draize j. H. 1959 - Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24, 48 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 48 h
- Remarks on result:
- other: intact site
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24, 48 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 48 h
- Remarks on result:
- other: abraded site
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24, 48 h
- Score:
- 1.83
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 48 h
- Remarks on result:
- other: intact site
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24, 48 h
- Score:
- 1.67
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 48 h
- Remarks on result:
- other: abraded site
- Irritant / corrosive response data:
- The test material produced severe cutaneous irritation at both intact and abraded sites of all test animals. At 4 hours all test sites had become necrotic. The skin had become hard to touch and black in colour with slight oedema around the periphery. At 24 hours all test sites were covered with a hard black crust which was consistent with irreversible tissue destruction (necrosis). Similar effects were apparent at the 48 and 96 hour readings. The test material produced tissue necrosis at 6/6, intact and 6/6 abraded sites and was defined as being a "corrosive substance". In addition, it was also defined as a severe skin irritant (primary irritation index 5 .8) .
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
skin irritation:
In a key skin irritation study, six New Zealand White rabbits were treated once with cyclopentylamine (conentration: 0.5 mL) via occlusive exposure for 4 hours and observed irritation effects for 48 hours. The test material produced severe cutaneous irritation at both intact and abraded sites of all test animals. At 4 hours all test sites had become necrotic. The skin had become hard to touch and black in colour with slight oedema around the periphery. At 24 hours all test sites were covered with a hard black crust which was consistent with irreversible tissue destruction (necrosis). Similar effects were apparent at the 48 and 96 hour readings. The test material produced tissue necrosis at 6/6, intact and 6/6 abraded sites and was defined as being a "corrosive substance".
Justification for selection of skin irritation / corrosion endpoint:
Only one key study is available.
Justification for selection of eye irritation endpoint:
In accordance with column 2 of REACH Annex VIII, the test eye irritation (required in section 8.2) does not need to be conducted if the available information indicates that the criteria are met for classification as corrosive to the skin or irritating to eyes, or the substance is flammable in air at room temperature.
Based on the results, the substance was classified and labelled as Skin Corr. 1B ( H314: Causes severe skin burns and eye damage.) and Flammable liquid cat 2 H225 Highly flammable liquid and vapour according to Regulation (EC) No 1272/2008 and as C; R34 Causes burns. and F, R11 Highly flammable. according to Directive 67/548/EEC (DSD).
Effects on skin irritation/corrosion: corrosive
Justification for classification or non-classification
Based on the results for skin irritation, the substance was classified and labelled as corrosive to the skin cat. 1B (H314: Causes severe skin burns and eye damage) according to Regulation (EC) No 1272/2008 and as corrosive (C, R34: Causes burns) according to Directive 67/548/EEC (DSD).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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