Registration Dossier
Registration Dossier
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EC number: 204-331-3 | CAS number: 119-53-9
Carcinogenicity
Administrative data
Description of key information
Citation:
Brady, A., H. Stack, AND M. Waters. GENETIC TOXICOLOGY OF BENZOIN AND CAPROLACTAM. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-89/384 (NTIS PB90216151), 1989.
Key value for chemical safety assessment
Justification for classification or non-classification
Additional information
Based on animal carcinogenesis studies, benzoin has been classified as noncarcinogens. The genetic toxicity of the compound has been thoroughly evaluated in short-term in vitro bioassays. Genetic activity profiles and corresponding data listings and summaries are presented for benzoin. Generally weak positive responses were obtained with benzoin only in mammalian cell mutagenesis and cell transformation assays. Since the chemical structure of benzoin do not suggest the potential for genotoxicity these responses may be associated with nonspecific toxicity. The overwhelming majority of short-term test data suggest that, in accordance with animal cancer data, benzoin is not genotoxic.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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