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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Toxicity screening report, limited information given only; no data on GLP compliance, no guideline mentioned. However, basic information given; sufficient for a classification decision.

Data source

Reference
Reference Type:
other: acute toxicity screening report
Title:
Unnamed
Year:
1991
Report date:
1991

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Test System Preparation:
The test site was prepared on each animal by clipping the trunk free of hair with electric clippers and a number 40 blade. Two test sites, one control site and one treated site, were selected on opposite sides of the dorsal midline.
Dosage and Administration:
The test material (0.5 g/test site) was applied, as received, moistened with tap water, to one inch square gauze patches and applied to the test site. The patches were held in place with adhesive tape and the trunk wrapped in an impervious wrap consisting of a sheet of plastic covered by filter cloth. After a four hour exposure period the wraps were removed and the test sites cleaned with gauze sponges and tap water to remove any remaining test material. The animals were examined at the stated intervals below using the Draize scale for evaluating the skin irritation potential of test materials.
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
5-methoxymethyl-2,3-pyridine-dicarboxylic acid
IUPAC Name:
5-methoxymethyl-2,3-pyridine-dicarboxylic acid
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Age at study initiation: 12-14 weeks
- Housing: Standard stainless steel cages with automatic watering.
- Diet (e.g. ad libitum): Purina Rabbit Chow (nonmedicated), available ad libitum


ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-26 °C
- Humidity (%): 30-70%

Test system

Type of coverage:
occlusive
Preparation of test site:
clipped
Vehicle:
other: test material was moistened with water
Controls:
other: one side of the dorsal midline served as control site.
Amount / concentration applied:
0.5 g
Duration of treatment / exposure:
4 hours
Observation period:
up to 72 hours
Number of animals:
3

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 4 hours
Score:
0.3
Max. score:
4
Reversibility:
fully reversible within: 24 hours
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 24 hours
Score:
0
Max. score:
4
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 48 hours
Score:
0
Max. score:
4
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 72 hours
Score:
0
Max. score:
4
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 4 hours
Score:
0
Max. score:
4
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 24 hours
Score:
0
Max. score:
4
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 48 hours
Score:
0
Max. score:
4
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 72 hours
Score:
0
Max. score:
4

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information
Conclusions:
Using the Draize scale for the evaluation of the effects described in the report, 5-methoxymethyl-2,3-pyridine-dicarboxylic acid does not need to be classified for skin irritation. However, the Draize scale was not attached to the report.