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EC number: 700-618-7 | CAS number: 39202-17-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Neurotoxicity
Administrative data
Description of key information
Using a read-across approach with the substance 9-decenoic acid, methyl ester, the test material 9-dodecenoic acid, methyl ester is not expected to be a neurotoxicant. No evidence of systemic toxicity (including neurotoxicity) of 9-decenoic acid, methyl ester was observed in 28-day and 90-day repeated dose toxicity studies at doses up to 1000 mg/kg bw/day (the highest dose tested).
Key value for chemical safety assessment
Effect on neurotoxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
Effect on neurotoxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Effect on neurotoxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The repeated dose toxicity of the test item 9-dodecenoic acid, methyl ester via the oral route has been read-across from the substance 9-decenoic acid, methyl ester from the following studies:
A 28 day repeat dose oral toxicity study combined with a reproduction/ developmental toxicity screening test was performed in the rat in accordance with GLP and OECD Guideline 422 (Harlan Laboratories Ltd, 2012). The test item, 9-decenoic acid, methyl ester was administered by gavage to three groups, each of ten male and ten female Wistar Han™:RccHan™:WIST strain rats, for up to eight weeks (including a two week pre-pairing phase, pairing, gestation and early lactation for females), at dose levels of 30, 300 and 1000 mg/kg bw/day. There were no treatment related effects observed on behavioural assessment, functional performance tests or sensory reactivity assessments. Since no treatment-related effects were observed, a NOAEL for systemic toxicity (including neurotoxicity) was considered to be 1000 mg/kg bw/day.
A 90 day repeat dose oral toxicity study was performed in the rat in accordance with GLP and OECD Guideline 422 (WIL Research, 2015). 9-Decenoic Acid, Methyl Ester (9DAME), was administered orally by gavage once daily for a minimum of 90 consecutive days to Crl:CD(SD) rats. Dosage levels were 100, 300, and 1000 mg/kg/day. Mortality, clinical signs, body weight, food consumption, neurobehavioral parameters, ophthalmology, and clinical pathology parameters (hematology, coagulation, serum chemistry, and urinalysis) were monitored during the study. Complete necropsies were conducted on all animals, and selected organs were weighed at the scheduled necropsies. Selected tissues were examined microscopically. The subchronic oral administration of 9-decenoic acid, methyl ester (9DAME) to rats by gavage did not result in any toxicologically significant effects. There were no treatment related effects observed on functional observational battery parameters or on motor activity. The subchronic NOAEL for systemic toxicity, including neurotoxicity, is therefore considered to be 1000 mg/kg bw/day.
Justification for selection of effect on neurotoxicity via oral route endpoint:
The effects on neurotoxicity of the test item 9-dodecenoic acid, methyl ester (9DDAME) via the oral route has been read-across from studies conducted with the substance 9-decenoic acid, methyl ester (9DAME). This study was conducted according to OECD Guideline 408 and to GLP and is adequately reported. As such the study has been assigned a reliability 1.
Justification for classification or non-classification
No systemic toxicological findings, including no evidence of neurotoxicity, were detected in rats after repeated administration of 9-decenoic acid, methyl ester (9DAME) by the oral route at dose levels up to 1000 mg/kg bw/day for periods of 28 or 90 days. Based on these results, using a read across approach, 9-dodecenoic acid, methyl ester (9-DAME) does not warrant classification for neurotoxicity according to the criteria described in Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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