Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-642-7 | CAS number: 144-83-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sediment toxicity
Administrative data
- Endpoint:
- sediment toxicity: short-term
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2011
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This is a publication result with a scientific method.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- Sulfapyridine
- EC Number:
- 205-642-7
- EC Name:
- Sulfapyridine
- Cas Number:
- 144-83-2
- Molecular formula:
- C11H11N3O2S
- IUPAC Name:
- 4-amino-N-pyridin-2-ylbenzenesulfonamide
- Details on test material:
- no data
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
no data
Sampling and analysis
- Analytical monitoring:
- no
- Details on sampling:
- no data
Test substrate
- Vehicle:
- no
- Details on sediment and application:
- Bacterial enzyme inhibition was measured after 4 h by applying a colorimetric assay.
Test organisms
- Test organisms (species):
- other: Arthrobacter globiformis
- Details on test organisms:
- The sediment contact assay with the soil bacterium Arthrobacter globiformis (DIN 38412-L48) was applied in the version modified for liquid samples (Neumann-Hensel and Melby, 2006). Through the activity of the bacterial dehydrogenases the blue Resazurin turned into the pink Resorufln, indicating healthy cells. A. globiformis is one of the most common aerobic chemohet- erotrophic bacteria in soils.
Study design
- Study type:
- laboratory study
- Test type:
- static
- Type of sediment:
- not specified
- Limit test:
- no
Exposure duration
- Duration:
- 4 h
- Exposure phase:
- total exposure duration
Test conditions
- Hardness:
- no data
- Test temperature:
- no data
- pH:
- no data
- Dissolved oxygen:
- no data
- Salinity:
- no data
- Ammonia:
- no data
- Nominal and measured concentrations:
- no data
- Details on test conditions:
- no data
- Reference substance (positive control):
- no
Results and discussion
Effect concentrations
- Duration:
- 4 h
- Dose descriptor:
- other: IC50
- Effect conc.:
- > 125 mg/L
- Conc. based on:
- test mat.
- Remarks on result:
- other: no more data available
- Details on results:
- no data
- Results with reference substance (positive control):
- no data
- Reported statistics and error estimates:
- The confidence interval (a = 0.05) of the IC50 value was calculated using the R language. The dose-response curve parameters and plots were obtained using the drift package (version 0.05-92) for the R language and environment for statistical computing (www.r-pro- ject.org) as well as SigmaPlot Version 10.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The IC50 was>125 mg/l for the soil bacteria Arthrobacter globiformis.
- Executive summary:
The sediment contact assay with the soil bacterium Arthrobacter globiformis (DIN 38412-L48) was applied in the version modified for liquid samples (Neumann-Hensel and Melby, 2006). Bacterial enzyme inhibition was measured after 4 h by applying a colorimetric assay.The IC50 was>125 mg/l for the soil bacteria Arthrobacter globiformis.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.