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EC number: 203-897-9 | CAS number: 111-70-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Summary results of the key studies are as follows:
· Skin irritation potential (rabbit): slightly irritating (R. Truhaut, 1974))
· Eye irritation potential (rabbit): irritating (R. Truhaut, 1974))
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- New Zealand White
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: intact and abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 ml of non diluted sample
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 24 and 72 hours
- Number of animals:
- 6 rabbits
- Details on study design:
- 0.5 ml of heptanol was applied on 6 rabbits with intact skin and 6 rabbits with or abraded skin.
SCORING SYSTEM: according to the DRAIZE scoring. - Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24h+72h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: intact skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24h+72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: intact skin
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24h+72h
- Score:
- 0.75
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: abraded skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24h+72h
- Score:
- 0.25
- Max. score:
- 4
- Reversibility:
- no data
- Remarks on result:
- other: abraded skin
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information not classified. Criteria used for interpretation of results: EU
- Conclusions:
- n-heptanol is considered as a slightly irritant.
- Executive summary:
The acute dermal irritation of n-heptanol-1 was evaluated in rabbits according to OECD 404 guideline. n-heptanol-1 was applied undiluted to the skin of 6 New-Zealand White albino rabbits and held in contact for 4 hours by means of a semi-occlusive dressing. Mean scores over 24, and 72 hours were 0.75 and 0.25 for erythema and for edema, respectively. Under these experimental conditions, n-heptanol 1 was considered a slightly irritant when applied topically to rabbits.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- New Zealand White
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: non exposed eye
- Amount / concentration applied:
- 0.1 ml
- Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- 1, 2, 3, 4 and 7 days
- Number of animals or in vitro replicates:
- 6 rabbits
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.16
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.94
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.22
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Interpretation of results:
- Category II
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- n-heptanol-1 is considered as irritating to eyes.
- Executive summary:
The potential of n-heptanol-1 to induce ocular irritation was evaluated in rabbits according to OECD (No. 405) guideline. A single dose of 0.1mL of the undiluted test item was instilled into the conjunctival sac of the eye of 6 rabbits. The eyes were not rinsed after administration of the test item.
Ocular reactions were observed approximately 1 hour, 24, 48 and 72 hours after the administration. Mean scores calculated over 24, 48 and 72 hours were 0.22 for chemosis, 0.94 for redness of the conjunctiva, 0.0 for iris lesions and 1.16 for corneal opacity. We observed that the test item indiced slght opcity of the cornea with a slght irritation of the conjonctive. The irritation is at maximum at 72 hours and reverse progressively. 4/6 rabbits did not present signs of irritation after 7 days. Under these experimental conditions, n-heptanol-1 was irritant when administered by ocular route to rabbits.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation study
The acute dermal irritation of n-heptanol-1 was evaluated in rabbits according to OECD 404 guideline. n-heptanol-1 was applied undiluted to the skin of 6 New-Zealand White albino rabbits and held in contact for 4 hours by means of a semi-occlusive dressing. Mean scores over 24, and 72 hours were 0.75 and 0.25 for erythema and for edema, respectively. Under these experimental conditions, n-heptanol 1 was considered slightly irritant when applied topically to rabbits.
Eye irritation
The potential of n-heptanol-1 to induce ocular irritation was evaluated in rabbits according to OECD (No. 405) guideline. A single dose of 0.1mL of the undiluted test item was instilled into the conjunctival sac of the eye of 6 rabbits. The eyes were not rinsed after administration of the test item.
Ocular reactions were observed approximately 1 hour, 24, 48 and 72 hours after the administration . Mean scores calculated over 24, 48 and 72 hours were 0.22 for chemosis, 0.94 for redness of the conjunctiva, 0.0 for iris lesions and 1.16 for corneal opacity. WE observed that the test item indiced slght opcity of the cornea with a slght irritation of the conjonctive. The irritation is at maximum at 72 hours and reverse progressively. 4/6 rabbits did not present signs of irritation after 7 days. Under these experimental conditions, n-heptanol-1 was irritant when administered by ocular route to rabbits.
Effects on skin irritation/corrosion: slightly irritating
Effects on eye irritation: irritating
Justification for classification or non-classification
According to REGULATION (EC) No 1272-2008:
Skin irritation: not classified
The mean scores for erythema and oedema over 24, 48 and 72 hours obtained were below the threshold for classification (>= 2.3). The slight skin irritation observed was not fully reversible within 7 days.
Eye irritation: Irritant, category 2
The mean scores calculated over 24, 48 and 72 hours were 1.16 for corneal opacity (thresholf fo classification >=1 for 2/3 animals).
The slight ocular opacity was not fully reversible within 7 days in only 2/ 6 animals.. No observation were performed after the 7-day observation period, therefore we are unable to conclude on the reversibility of the effects. However taking into account the ocular toxicity of comparable compound (hexanol, octanol are classified ocular irritant category 2), it is concluded that heptanol is classified irritant category 2).
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