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EC number: 611-084-9 | CAS number: 54041-17-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity, rat:
The test substance is moderately toxic to rats following acute oral administration.
Some of the signs that were observed occurred immediately after administration and continued until day 5 maximum. Essentially, the following signs were observed: impaired activity and dyspnea, lethargy, piloerection, spastic or staggering gait, lateral recumbency, increased salivation, atony, convulsions, spasmodic state, no reflexes. Mortalities occurred starting at a dose of 400 mg/kg body weight.
LD50: Rat male: 726 mg/kg body weight (approximate)
LD50: Rat female: 474 mg/kg body weight (approximate)
Acute inhalation, rat:
The test substanceexhibited a slight acute inhalation toxicity in rats. The death and the clinical signs of the animals are regarded as causally related to an irritant effect of the test substance on the respiratory tract. In addition to nonspecific effects to the central nervous systems, the rats exposed to the 6802 mg/m3 exhibited clear signs of an irritant effect: bradypnea and labored breathing including gasping, rales, serous nasal discharge, bloody incrustations around the nose, hypothermia and corneal opacity.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March - April 1992
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- 1987
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
- Specific details on test material used for the study:
- Purity: 99.2 %
Stability in formulation not tested - Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- with 2% Cremophor EL (v/v)
- Doses:
- male: 1000, 800 and 500 mg/kg bw
female: 500, 400 and 200 mg/kg bw - No. of animals per sex per dose:
- 5 anmials per sex and dose
- Control animals:
- no
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 726 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 474 mg/kg bw
- Based on:
- test mat.
- Mortality:
- male: 1000 mg/kg group: 4 animals died, 800 mg/kg group: 3 animals died, 500 mg/kg group: no animal died
female: 500 mg/kg group: 3 animals died, 400 mg/kg group: 1 animal died, 200 mg/kg group: no animal died - Clinical signs:
- other: The following signs were observed in males at 500 mg/kg body weight and in females at 200 mg/kg body weight: piloerection, reduced or increased activity, dyspnea, spasmodic state, lateral recumbency, and spastic or staggering gait. In the males, letharg
- Gross pathology:
- Animals that died during the recovery period:
In a few cases, lungs pale, distended; in a few cases, liver dark, pale, mottled, lobular pattern; kidneys pale and mottled; spleen somewhat pale; in one animal, ulcer-like foci in the glandular stomach; in one animal, stomach with clear fluid or yellowish fluid content; in one animal, small intestine slightly reddened, empty; in a few cases, intestinal tract empty, reddened; mesenteric vessels severely injected; in a few cases, abdominal organs not assessable.
Animals sacrificed while moribund:
One animal: liver pale, mottled, lobular pattern; stomach with brown fluid content; glandular stomach reddened; intestinal tract reddened, partially empty.
Animals sacrificed at the end of the recovery period:
For males, no evidence of test substance-related, gross organ damage.
For females, at 500 mg/kg body weight: in a few cases, lungs slightly distended; liver with slight lobular pattern (one animal). - Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The substance is harmful if swallowed.
- Executive summary:
Tests were performed to determine the acute oral toxicity to male and female rats. The study was performed in accordance with the OECD Guideline for Testing of Chemicals; Section 4: Health Effects, No. 401 - "Acute Oral Toxicity," adopted February 24, 1987 (1) and in accordance with the Pesticide Assessment Guidelines, Subdivision F, Hazard Evaluation: Human and Domestic Animals, Series 81-1 Acute Oral Toxicity Study (Revised Edition, November 1984) (2).
LD50: Rat male: 726 mg/kg body weight (approximate)
LD50: Rat female: 474 mg/kg body weight (approximate).
Some of the signs that were observed occurred immediately after administration and continued until day 5 maximum. Essentially, the following signs were observed: impaired activity and dyspnea, lethargy, piloerection, spastic or staggering gait, lateral recumbency, increased salivation, atony, convulsions, spasmodic state, no reflexes. Mortalities occurred starting at a dose of 400 mg/kg body weight. The test substance is moderately toxic to rats following acute oral administration.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 474 mg/kg bw
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- January 23, 1992 - February 11, 1992
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- no
- Specific details on test material used for the study:
- Purity: 99.2 %;
stability in vehicle tested and confirmed - Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose/head only
- Vehicle:
- air
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- male and female:
group 1: air control
group 2: vehicle control (polyethylene glycol 400/acetone)
group 3: 2500 nominal (301 maeasured, in vehicle); test substance-vehicle-mixture, test substance diluted to 10% (w/v)
group 4: 6802 (measured) mg/m³ - No. of animals per sex per dose:
- 5 animals each.
- Control animals:
- yes
- Key result
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- ca. 6 800 mg/m³ air (nominal)
- Based on:
- test mat.
- Key result
- Sex:
- female
- Dose descriptor:
- other: NOEL
- Effect level:
- < 301 mg/m³ air (nominal)
- Based on:
- test mat.
- Mortality:
- 3 femals of dose group 4 died.
- Clinical signs:
- irregular respiration
- Remarks:
- effects regarded as indicative of an irritant effect of the test substance: bradypnea and labored breathing including gasping, rales, serous nasal discharge, bloody incrustations around the nose, hypothermia, corneal opacity
- Body weight:
- A temporary body weight loss was determined for the animals of Groups 3 and 4.
- Gross pathology:
- Rats sacrificed at the end of the recovery period: No particular indications of substance-induced effects were found. The not completely collapsed lungs in two females of Group 4 are regarded as sacrifice-related findings.
Rats that died during the studv: Lungs not completely collapsed, reddish and mottled; liver pale and with lobulation; spleen pale; glandular stomach with bloody ulcerative changes; duodenum reddish and with mucoid, yellowish-black and bloody content, kidneys pale; renal pelvis reddish. - Other findings:
- nonspecific clinical signs (piloerection and unpreened fur, reduced motility, vocalization, staggering gait, atony, sternal recumbency, comatose state, body weight loss, impairment of the pinnal reflex, the reaction to noises and righting reflex)
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- LC50 Inhalation (Exposure: 4 hours);
Rat female : approx. 6800 mg/m3 (6.8 mg/l);
NOEL < 301 mg/m3 - Executive summary:
Tests were performed to determine the acute inhalation toxicity in accordance with OECD Guideline No. 403.
The test substance-aerosol exhibited a slight acute inhalation toxicity in rats. The death and the clinical signs of the animals are regarded as causally related to an irritant effect of the test substance on the respiratory tract. In addition to nonspecific effects to the central nervous systems, the rats exposed to the 6802 mg/m3 exhibited clear signs of an irritant effect: bradypnea and labored breathing including gasping, rales, serous nasal discharge, bloody incrustations around the nose, hypothermia and corneal opacity.
Reference
Group | Concentration (mg/m3) | Tox results | Duration of signs | Time of death | Particles ≤ 3µm (5) | |
nominal | analyt. | male rats | ||||
1 | air control | 0/0/5 | - | - | - | |
2 | Vehicle control | 0/5/5 | 4-5h | - | 93 | |
3 | 2500 | 301 | 0/0/5 | - | - | 89 |
4 | - | 6802 | 0/5/5 | 4h-11d | - | 69 |
Group | Concentration (mg/m3) | Tox results | Duration of signs | Time of death | Particles ≤ 3µm (5) | |
nominal | analyt. | female rats | ||||
1 | air control | 0/0/5 | - | - | - | |
2 | Vehicle control | 0/5/5 | 4-5h | - | 93 | |
3 | 2500 | 301 | 0/0/5 | - | - | 89 |
4 | - | 6802 | 3/5/5 | 4h-5d | 1d | 69 |
LC50 (females): approximately 6800 mg/m3
Group 1: 15 liters air/minute
Group 2: 1000 /µl vehicle (polyethylene glycol 400/acetone)/minute, 15 liters air/minute
Group 3: 375/µl test substance-vehicle-mixture/minute, test substance diluted to 10% (w/v) in vehicle, 15 liters air/minute
Group 4: Collision-Nebulizer: 6 liters air/minute + 17 liters dilution air/minute
The numbers in the "Tox. Results" column of Table 1 have the following meanings:
1st number = number of animals that died
2nd number = number of animals with signs
3rd number = number of animals tested
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 6 800 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Based on the study results for acute toxicity allocation to category 4 for oral toxicity (H302) and no classification for inhalative toxicity according to Regulation (EC) No. 1272/2008 (CLP), ANNEX I, is warranted.
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