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Diss Factsheets
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EC number: 222-321-7 | CAS number: 3425-61-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Based on physico-chemical properties (low molecular weight, moderate log Ko/w, high water solubility), TAHP is likely to penetrate human body by oral, dermal and inhalation exposure.
Tert-amyl hydroperoxide (TAHP) is a colourless liquid with a molecular weight of 104.1 g/mol. The substance is soluble in water (63.25 g/L à 25 °C). The logKow of TAHP is estimated to be around 2.9. TAHP has a relatively high vapor pressure: 43.20 hPa at 25 °C. The calculated log BCF is 1.580: there is no bioaccumulation potential.
TAHP does not rapidly degrade hydrolytically at pH 4, 7 and 9 for 5 days at 50°C (half live > 1 year). At pH 1.2 and 37°C for 2 and 4 hours, no hydrolysis of the 0.01 M TAHP solution (1.04 g/L) was observed.
Therefore no tert-amyl alcohol is expected to be formed in stomach neither in rats nor in humans, unless an enzymatic transformation occurs.Oral absorption is favored for molecular weights below 500 g/mol. Based on the moderate logKow and the high water solubility, TAHP can be regarded as a hydrophilic substance. Based on these physico-chemical properties it can be assumed that significant absorption across the gastrointestinal tract epithelium may occur when administered in repeated dosages. This is confirmed by acute oral toxicity data, in which systemic effects were observed.
Based on the high vapor pressure, inhalation is the most reliable route of exposure. In addition the small size of the molecule, its water solubility and its mild logKow are in favor of inhalation uptake. Together, this indicates relatively high systemic availability after inhalation.
Based on physical – chemical properties of TAHP, the substance is likely to penetrate skin. In addition, application of TAHP to skin of rabbits is responsible of severe skin damages, which could enhance the skin absorption. Applied to the skin of guinea pigs, sensitizing effects were observed, indicating that at least small amounts of the substance become available in the body. In addition, systemic effects were observed after a single dermal administration, showing that the substance (or its metabolite) is systemically available.
In conclusion, 100 % of tert-amyl hydroperoxide is considered to be absorbed by inhalation, by oral route and by dermal route.
There is no information on metabolism and toxicokinetic for TAHP. Nevertheless, it is expected that TAHP hydrolyses quickly in the blood in tert-amyl alcohol by an enzymatic way.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 100
- Absorption rate - inhalation (%):
- 100
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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