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EC number: 200-826-3 | CAS number: 74-97-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17 Sep 1997 -19 Nov 1997
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 798.1150 (Acute inhalation toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Bromochloromethane
- EC Number:
- 200-826-3
- EC Name:
- Bromochloromethane
- Cas Number:
- 74-97-5
- Molecular formula:
- CH2BrCl
- IUPAC Name:
- bromo(chloro)methane
- Reference substance name:
- 2008263
- IUPAC Name:
- 2008263
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River France, 59 rune de la Paix, 76140 SAINT-AUBIX-LES ELBEUF (FRANCE).
- Age at study initiation: 8-10 weeks
- Weight at study initiation: The males weight ware: 283 to 294 g. The females weight were: 219 to 248 g.
- 5 days of acclimatisation before start of study.
-Free access of water and food.
- Housing: Solid-floor polypropylene cages
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 ± 2 ºC
- Humidity (%): 55±15 %
- Air changes (per hr): at least 15 changes per hr.
- Photoperiod (hrs dark / hrs light): 12 / 12
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Details on inhalation exposure:
- TYPE OF INHALATION EXPOSURE: Nose only
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Incubation chamber with a capacity of 30 liters
- Method of holding animals in test chamber: each rat was held in tapered tube which was fitted onto a tier of the exposure chamber
- System of generating particulates/aerosols:
- Temperature, humidity in air chamber: 21 ± 2 ºC, 55±15 % humidity.
- Air change rate: at least 15 air changes per hour.
- Method of particle size determination: NDA
- Treatment of exhaust air: NDA
TEST ATMOSPHERE
- Brief description of analytical method used: an electronic termometer/humidity meter measured every 30 min. in the 4 hours exposure.
- Samples taken from breathing zone: pumping known amount into a glass containing acetone. - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- by gas chromatography.
- Duration of exposure:
- 4 h
- Concentrations:
- Exposure chamber mean achieved concerntration was 38.6 mg/l
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Clinical observations made immediately on removal from the restraining tubes at the end of exposure,
1 hour after termination of exposure and at least once a day for 14 days. Body weights recorded on days: day of exposure, 7,14 or at death.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, macroscopic examination of respiratory tract. - Statistics:
- NDA
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 38.6 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- One female was found dead on completion of exposure and one male was found dead after 2 hr and 21 min after exposure.
- Clinical signs:
- other: Clinical signs observed included wet fur and increased or decreased respiratory rate and laboured respirations and fasciculations. 8 survivors were comatose and hypothermicm hunched posture, loss of righting reflex, lethargy, pilo-erection, ataxia, noi
- Body weight:
- During week 1- one male showed no gain in bodyweight and possible reduction in bodyweight gain was noted in several other survivors.
Noraml bodyweight gain was noted during week 2. - Gross pathology:
- Lung abnormalities were found. they included haemorrhage, swelling, abnormal darkening, dark patches, pale patches and dark foci
- Other findings:
- N/A
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- The acute inhalation LC50 of the test substance Bromochloromethane was greater than 38.6 mg/l.
- Executive summary:
An acute inhalation toxicity was perfomed on 5 males and 5 female Sprague Dawley rats with mean achieved concentration of 38.6 mg/l. The test followed OECD guideline 403 and was performed to GLP standard.
Only 2 mortality cases were observed. Therefore, the LC50 of the test substance Bromochloromethane was determined to be greater than 38.6 mg/l.
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