Registration Dossier
Registration Dossier
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EC number: 234-196-6 | CAS number: 10591-84-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: reported in brief but sufficient information for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
- Principles of method if other than guideline:
- 500 mg of the testsubstance were applied to the inner surface of one ear of each of 2 New Zealand White rabbits held in place by plaster for 24 hours. After termination of the exposure the ear was cleaned with water, soap and oil and the animals were observed for further 7 days
- GLP compliance:
- not specified
Test material
- Reference substance name:
- N,N'-dimethyldiphenylthiuram disulphide
- EC Number:
- 234-196-6
- EC Name:
- N,N'-dimethyldiphenylthiuram disulphide
- Cas Number:
- 10591-84-1
- Molecular formula:
- C16H16N2S4
- IUPAC Name:
- N-methyl-N-phenyl{[methyl(phenyl)carbamothioyl]disulfanyl}carbothioamide
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- 98.1 %
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- body weight at study inititiation: 3-4 kg
male and female
housing: individually
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: the other ear (inner surface)
- Amount / concentration applied:
- 500 mg
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 7 days
- Number of animals:
- 2
- Details on study design:
- 500 mg of the testsubstance were applied to the inner surface of one ear of each of 2 New Zealand White rabbits held in place by plaster for 24 hours. After termination of the exposure the ear was cleaned with water, soap and oil and the animals were observed for further 7 days
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: at the end of the observation period
- Score:
- ca. 0
- Reversibility:
- other: the substance caused no irritation
- Irritant / corrosive response data:
- the substance caused no irritation
- Other effects:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Executive summary:
500 mg of the testsubstance were applied to the inner surface of one ear of each of 2 New Zealand White rabbits and held in place by plaster for 24 hours. After termination of the exposure the ear was cleaned with water, soap and oil and the animals were observed for further 7 days. Vulcacit I caused no irritation (Mihail 1977).
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