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EC number: 700-073-5 | CAS number: 1215036-04-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from September 28,2007 to October 26,2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: recent report; GLP conditions; OECD guideline followed
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Deviations:
- yes
- Remarks:
- In addition, degradation was followed by T.O.C. analysis at frequent intervals over the 28 days period. This measurement of carbon content was considered as not relevant due to the behaviour of the test item in the test medium.
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Isosorbide Diesters
- EC Number:
- 700-073-5
- Cas Number:
- 1215036-04-6
- Molecular formula:
- As it is an UVCB, we can not provide the exact molecular formula.
- IUPAC Name:
- Isosorbide Diesters
- Details on test material:
- - Name of test material (as cited in study report): LAB 3822
- Physical state: liquid
- Lot/batch No.: FAL 07/25
- Expiration date of the lot/batch: 2009
- Storage condition of test material: at room temperature but preferably between 10 and 15°C
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic (adaptation not specified)
- Details on inoculum:
- The inoculum was prepared from activated sludge sampled in the aeration tank treatment plant receiving predominantly domestic sewage (Montataire - (60) France). The supernatant of this activated sludge was used as inoculum.
- Duration of test (contact time):
- 28 d
Initial test substance concentrationopen allclose all
- Initial conc.:
- 10 mg/L
- Based on:
- DOC
- Initial conc.:
- 20 mg/L
- Based on:
- DOC
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- TEST CONDITIONS
- Composition of medium: abiotic
- Test temperature: regulated room ,20-23°c
- mineral medium pH: 7.45
- Aeration of dilution water: carbon dioxide-free air
- Continuous darkness: yes
TEST SYSTEM
- Culturing apparatus:
- Number of culture flasks/concentration: 8
- Method used to create aerobic conditions: carbon dioxide-free air
- Measuring equipment: carbon analyser : Shimadzu TOC VSCN and SSM 5000A
- Test performed in open system: yes
- Details of trap for CO2 and volatile organics if used: CO2 is trapped as BaCO3 in barium hydroxide (Ba(OH)2) and is measured by titration of the residual 0.0125 M Ba(OH)2 with a 0.05M HCL solution in presence of phenolphtalein.
- Frequency : each of 2 or 3 days
CONTROL AND BLANK SYSTEM
- blank control : only inoculum
- inoculum control:aniline 20mg/l + inoculum
- Toxicity control: HgCl2
Reference substance
- Reference substance:
- aniline
Results and discussion
% Degradation
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 83
- Sampling time:
- 28 d
- Details on results:
- The pass level for ready biodegradability, 60% of ThCO2, has been reached in a 10-d window and the CO2 production in the test suspension is relatively gradually during the test period.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The level of degradation of the LAB 3822 has reached 83% ThCO2 within a 28 day-period, criteria for good evidence of "ready biodegradability" were respected in test conditions.
- Executive summary:
The biodegradability of LAB3822 is evaluated by the determination of the carbon dioxide produced by the test item degradation. The test method is OECD Guideline for the testing of chemicals 301 B: CO2 Evolution Test (17 july 1992). The test concentrations are 10 and 20 mg/l as organic carbon (O.C.) (nominal, initial concentrations). The reference item is aniline, 20mg/l (O.C.). Inoculum is prepared from activated sludge from a treatment plant receiving predominantly domestic sewage. The duration is 28 days.
RESULTS :
LAB 3822 ANILINE 10mg C/L 20mg C/L 20mg C/L 79.1% 86.2% 97% Mean : 83% / The level of degradation of the LAB 3822 has reached 83% ThCO2 within a 28 day-period, criteria for good evidence of "ready biodegradability" were respected in test conditions.
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