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EC number: 615-240-7 | CAS number: 710292-85-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Formaldehyde, telomer with 1,3-benzenedimethanamine, 1,3-benzenediol and ethenylbenzene
- EC Number:
- 615-240-7
- Cas Number:
- 710292-85-6
- Molecular formula:
- Not available for this UVCB
- IUPAC Name:
- Formaldehyde, telomer with 1,3-benzenedimethanamine, 1,3-benzenediol and ethenylbenzene
- Test material form:
- other: waxy solid
- Details on test material:
- commercial sample. no data on purity
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Charles River Deutschland GmbH
Sandhofer Weg 7
D-97633 Sulzfeld
- Age at study initiation: 34 d
- Weight at study initiation: 172 - 200 g
- Fasting period before study: yes
- Housing: Granulated textured wood (Granulate A2, J Brandenburg, D-49424 Goldenstedt) was used as bedding material for the cages The cages were changed and cleaned twice a week. Periodic analysis of the bedding material for contaminants based on EPA/USA is conducted at least once a year by LUFA-ITL. During the 14-day observation period the animals are kept singly in MAKROLON cages (type Ill) at a room temperature of 22° C ± 3 ° C (maximum range) and a relative humidity of 60% ± 20% (maximum range). The rooms were lit (150 lux at approx 1 50 m room height) and darkened for periods of 12 hours each.
- Diet (e.g. ad libitum): Altromin 1324 (ALTROMIN GmbH, D-32791 Lage/Lippe, composition see Appendix 1) served as food. Feeding was discontinued approx 16 hours before administration, only tap water was then available ad libitum.
Periodic analysis of the food for contaminants based on EPA/USA1 is conducted at least twice a year by LUFA-11-L2 (limitation for contaminants in the diet see Appendix 2).
- Water (e.g. ad libitum):Drinking w ater in bottles was offered ad libitum. Drinking water is examined according to the 'Deutsche Trinkwasserverordnung, Bun¬desgesetzblatt, Jahrgang 1990' by the Hamburger Wasserwerke, D-20539 Hamburg, at least four times a year (limitation for contaminants in the drinking water see Appendix 1).
- Acclimation period: 5 days
IN-LIFE DATES: From: October 7th, 1999 to October 21st, 1999
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: sesame oil
- Details on oral exposure:
- A dose level of 2000 mg/kg bw, at 10 ml per kg bw, was tested in 5 males and 5 females (Limit-test).
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Following administration, observations were made and recorded systematically with individual records being maintained for each animal. Observations were performed before and immediately, 5, 15, 30 and 60 min, as well as 3, 6 and 24 hours after ad¬ministration. All surviving animals were observed. Observations on mortality were made at least once daily with appropriate actions taken to minimize loss of animals during the study. Individual body weights were recorded before administration of the substance and thereafter in weekly intervals up to the end of the study, and at death. Changes in weight were calculated when survival exceeds one day
At the end of the experiments all surviving animals were sacrificed, dissected and inspected macroscopically. All gross pathological changes were recorded. From ani¬mals which survive 24 hours or longer a microscopic examination of all organs which showed evident lesions was performed, if necessary. Autopsy and macroscopic in¬spection of animals which died prematurely were carried out as soon as possible after exitus. - Statistics:
- no data
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: no mortality
- Mortality:
- No mortality
- Clinical signs:
- other: no clinical signs
- Gross pathology:
- No pathology, no microscopic examinations
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The substance, when administered by gavage in oil to Sprague-Dawley rats (male and female) in a limit test of 2000 mg/kg bw, resulted in no deaths. The LD50 is over 2000 mg/kg bw.
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