Tetradecyl acrylate

Acute Toxicity: other routes

Administrative data

Endpoint:

acute toxicity: other routes

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1962

Report date:

1962

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

The study was conducted according to an internal BASF method. Several groups of 5 mice per dose were treated intraperitoneally with preparations of the test substance in aqueous emulsion with traganth.

GLP compliance:

no

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-Propenoic acid, C12-14-alkyl esters

EC Number:

282-516-8

EC Name:

2-Propenoic acid, C12-14-alkyl esters

Cas Number:

84238-60-8

Molecular formula:

Unspecified

IUPAC Name:

2-Propenoic acid, C12-14-alkyl esters

Test animals

Species:

mouse

Strain:

other: Hannover

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Breeder: BASF AG

Administration / exposure

Route of administration:

intraperitoneal

Vehicle:

other: aqueous emulsion with traganth

Doses:

3.2, 2.5, 2.0, 1.6, and 0.2 mL/kg bw (corresponding to 2784, 2175, 1740, 1392, and 174 mg/kg bw)

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

Group-wise documentation of clinical signs was performed over the 7-day study period. Body weight was determined before the start of the study only, as it was needed for determination of dose. The clinical signs and findings were reported in summary form. Upon completion of the study, all animals were sacrificed and submitted to gross-pathological examination.

Statistics:

On the basis of the observed lethality, the LD50 value was estimated using a graphical evaluation of the dose response curve on probability paper.

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

ca. 1 910 mg/kg bw

Based on:

test mat.

Remarks on result:

other: Exposure time: 168 hour(s)

Mortality:

- 174 mg/kg bw: All animals at this dose level survived until the end of the observation period.
- At the highest dose level, deaths occurred 48 h (4) and 72 h (1) after administration of the test compound. At 2175 mg/kg bw, 2 animals died within the first 24 hours after test start, then on day 4 and 5 one animal died, respectively (delayed mortality).

Clinical signs:

- 174 mg/kg bw: On the day of test substance administration clinical signs observed were: slight apathy, ruffled fur and sunken flanks. At the 24 hours observation, these clinical signs had completely subsided.
- 1392 - 2787 mg/kg bw: At these dose levels, clinical signs on the day of test substance administration were also: ruffled fur and sunken flanks. Most animals showed a calm demeanor, and some apathy. After approx. 4 days the surviving animals were without clinical finding.

Gross pathology:

Gross-pathological examination of the animals sacrificed at the end of the experiment revealed slight intraperitoneal agglutinations and encapsulated abscesses in the abdominal wall.

Any other information on results incl. tables

Mortality:

  Dose              Cumulative mortality after
 [mg/kg bw]     1 h     24 h     48 h     7 d      
-------------------------------------------------
  2787          0/5      0/5      4/5     5/5    
  2175          0/5      2/5      2/5     4/5     
  1740          0/5      0/5      0/5     0/5     
  1392          0/5      0/5      0/5     1/5     
   174           0/5       0/5      0/5    0/5     
-------------------------------------------------