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Diss Factsheets
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EC number: 203-113-5 | CAS number: 103-45-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline-comparable study with limited methodological detail but sufficient for the purposes of hazard identification and classification
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 965
- Report date:
- 1965
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-4 (Acute Eye Irritation)
- Version / remarks:
- Study pre-dates introduction of the formal guideline
- Principles of method if other than guideline:
- Three rabbits treated by ocular instillation according to the method developed by Draize and published by the Association of Food and Drug Officials of the United States as "Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics".
0.1 mL of the test substance was instilled into the right eye. - GLP compliance:
- no
Test material
- Reference substance name:
- Phenethyl acetate
- EC Number:
- 203-113-5
- EC Name:
- Phenethyl acetate
- Cas Number:
- 103-45-7
- Molecular formula:
- C10H12O2
- IUPAC Name:
- 2-phenylethyl acetate
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: The untreated eye acted as a concurrent control for each treated rabbit.
- Amount / concentration applied:
- 0.1 ml instilled into right eye of each rabbit
- Duration of treatment / exposure:
- The exposure was not limited by a wash-out for the treated eye. Potential continuous exposure was monitored for up to 7 days.
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- Three rabbits
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): No information
SCORING SYSTEM: standard Draize assessment
TOOL USED TO ASSESS SCORE: hand-slit lamp / biomicroscope / fluorescein : No information
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 day observation period
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.67
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.89
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Instillation of phenyl ethyl acetate into the right eye of three rabbits resulted in persistent corneal, iridial and conjunctival reactions that had not resolved at termination on Day 7.
The mean scores for the ocular parameters over the 24 to 72 hour timepoints for corneal, iridial and conjunctival reactions were lower than the classification thresholds but the persistence of reactions requires classfication of phenylethyl acetate as R41 Eye Irritant. - Executive summary:
In a three rabbit ocular irritation assessment, phenylethyl acetate elicited a degree of corneal opacity and some iritis together with conjunctival redness and swelling. Although none of the individual parameter mean scores would warrant classification of the test substance, the persistence of the reactions to termination with no signs of resolution warrants classification as an eye irritant (Category 1) according to CLP. H318 Causes serious eye damage.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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