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EC number: 204-688-5 | CAS number: 124-19-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1988-11-08 to 1988-11-15
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well docmented and acceptable for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EC Directive L251 of 1984-04-25
- Principles of method if other than guideline:
- 4 rabbits dermally exposed to 0.5 mL of test material semi-occlusively for 4 hrs, observed for 7 d
- GLP compliance:
- yes
Test material
- Reference substance name:
- Nonanal
- EC Number:
- 204-688-5
- EC Name:
- Nonanal
- Cas Number:
- 124-19-6
- Molecular formula:
- C9H18O
- IUPAC Name:
- nonanal
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Nonanal, CAS No. 124-19-6
- Substance type: Fragrance material
- Physical state: Liquid
- Analytical purity: No data
- Impurities (identity and concentrations): No data
- Composition of test material, percentage of components: No data
- Isomers composition: No data
- Purity test date: No data
- Lot/batch No: No data
- Expiration date of the lot/batch: No data
- Stability under test conditions: No data
- Storage condition of test material: In the dark at approx. 4 °C
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Gorseside Rabbits, Northchurch, Berkhamsted, Hertfordshire, United Kingdom
- Age at study initiation: 10-12 wks
- Weight at study initiation: approx. 2 kg
- Housing: Individually in grid-bottomed metal cages
- Diet: Commercial antibiotic-free pellet diet ad libitum
- Water: Mains water ad libitum
- Acclimation period: ≥ 5 d
ENVIRONMENTAL CONDITIONS
- Temperature: 17- 23 °C typically; dropped to 5 °C temporarily during acclimation due to heating failure
- Humidity: 37 % - 68 %
- Air changes (per hr): No data
- Photoperiod: 12 hrs dark / 12 hrs light)
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Volume applied: 0.5 mL - Duration of treatment / exposure:
- 4 hrs
- Observation period:
- 7 d (observations at 1 hr, 24 hrs, 48 hrs, 72 hrs, 7 d)
- Number of animals:
- 4
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 cm square
- Type of wrap if used: Lint held in place with "Elastoplast" elastic adhesive bandage 10 cm wide
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Gentle swabbing with cotton wool in warm water.
- Time after start of exposure: 4 hrs
SCORING SYSTEM: Standard Draize
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal: 349
- Time point:
- other: Mean of 24, 48, 72 hrs
- Score:
- 2
- Reversibility:
- not reversible
- Remarks:
- within 7 d
- Irritation parameter:
- edema score
- Basis:
- animal: 349
- Time point:
- other: Mean of 24, 48, 72 hrs
- Score:
- 1.17
- Reversibility:
- not reversible
- Remarks:
- within 7 d
- Irritation parameter:
- erythema score
- Basis:
- animal: 370
- Time point:
- other: Mean of 24, 48, 72 hrs
- Score:
- 2
- Reversibility:
- not reversible
- Remarks:
- within 7 d
- Irritation parameter:
- edema score
- Basis:
- animal: 370
- Time point:
- other: Mean of 24, 48, 72 hrs
- Score:
- 1.5
- Reversibility:
- not reversible
- Remarks:
- within 7 d
- Irritation parameter:
- erythema score
- Basis:
- animal: 374
- Time point:
- other: Mean of 24, 48, 72 hrs
- Score:
- 2
- Reversibility:
- not reversible
- Remarks:
- within 7 d
- Irritation parameter:
- edema score
- Basis:
- animal: 374
- Time point:
- other: Mean of 24, 48, 72 hrs
- Score:
- 1
- Reversibility:
- not reversible
- Remarks:
- within 7 d
- Irritation parameter:
- erythema score
- Basis:
- animal: 381
- Time point:
- other: Mean of 24, 48, 72 hrs
- Score:
- 2.17
- Reversibility:
- not reversible
- Remarks:
- within 7 d
- Irritation parameter:
- edema score
- Basis:
- animal: 381
- Time point:
- other: Mean of 24, 48, 72 hrs
- Score:
- 2.17
- Reversibility:
- not reversible
- Remarks:
- within 7 d
- Irritant / corrosive response data:
- Marked desquamation at 7 d
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test substance was assessed for skin irritation in rabbits following a 4 hour exposure period. The results indicate that the test material was irritating to skin as the mean erythema score was 2.0 in all 4 animals which was equal to the threshold value of 2.0 under Regulation 67/548/EEC (DSD).
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