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EC number: 220-813-6 | CAS number: 2905-62-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
The 72h-NOEC for growth rate inhibition was 9.7 mg/L.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 33 mg/L
- EC10 or NOEC for freshwater algae:
- 9.7 mg/L
Additional information
The toxicity of the test material to the freshwater green alga Pseudokirchneriella subcapitata was investigated in accordance with the standardised guidelines OECD 201, EU Method C.3 and the OECD series on testing and assessment number 23 under GLP conditions. The study has been assigned a reliability score of 1 in line with the principles for assessing data quality as defined by Klimisch et al. (1997).
The test material was not completely soluble in test medium at the initial loading rate. A Water Soluble Fraction (WSF) was prepared at a loading rate of 100 mg/L and was used as the highest test concentration. Lower test concentrations were prepared by subsequent dilutions of the WSF in test medium.
A final test was performed based on the results of a preceding combined limit/range-finding test. Six exponentially growing algal cultures were exposed to an untreated control and three replicates per group were exposed to 10, 18, 32, 56 and 100 % of a WSF prepared at a loading rate of 100 mg/L. The initial algal cell density was 10⁴ cells/mL. The total exposure period was 72 hours and samples for analytical confirmation of actual exposure concentrations were taken at the start and at the end of the test period. The range tested based on average measured concentrations was 3.0, 5.2, 9.7, 17, and 31 mg/L.
Growth rates were in the range of the controls at the three lowest concentrations during the 72-hour test period, whereas the growth rates of algae exposed to concentrations from 17 and 31 mg/L were increasingly reduced. Statistically significant inhibition of growth rate was found at test concentrations of 5.2 mg/L and higher. As the exposure to concentrations of 9.7 mg/L and less did not cause more than 10 % inhibition of growth rates, they were considered biologically irrelevant.
Reduction of yield increased with increasing concentration of the test material at all concentrations, resulting in 91% reduction at 31 mg/L. Statistically significant reduction of yield was found at all test concentrations. As the exposure to concentrations of 3.0 mg/L did not cause more than 10 % inhibition of yield, this concentration was considered biologically irrelevant.
The study met the acceptability criteria prescribed by the study plan and was considered valid.
Under the conditions of the study, the 72 h EC50 for growth rate inhibition and yield inhibition were 33 mg/L (95 % CI 32 to 35 mg/L) and 15 mg/L (95 % CI 14 to 16 mg/L), respectively. The 72 h NOEC for growth rate inhibition and yield inhibition were 9.7 and 3.0 mg/L, respectively.
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