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EC number: 223-578-8 | CAS number: 3965-55-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Remarks:
- Repeated Sublethal Testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1959
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 959
- Report date:
- 1959
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Rats were exposed 4 h per day for 9 days within a 14-day period to a single concentration (32 mg/L) of the test substance (whole body exposure). The study predates OECD guidelines.
- GLP compliance:
- no
- Remarks:
- study was performed prior to implentation of GLP
- Limit test:
- yes
Test material
- Reference substance name:
- Sodium dimethyl 5-sulphonatoisophthalate
- EC Number:
- 223-578-8
- EC Name:
- Sodium dimethyl 5-sulphonatoisophthalate
- Cas Number:
- 3965-55-7
- Molecular formula:
- C10H10O7S.Na
- IUPAC Name:
- sodium 3,5-bis(methoxycarbonyl)benzenesulfonate
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: ChR-CD
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- > 75 % of particles were < 3 µm in diam.
- Analytical verification of doses or concentrations:
- yes
- Details on analytical verification of doses or concentrations:
- no data
- Duration of treatment / exposure:
- 4 hours exposures, 9 during 2-week period.
- Frequency of treatment:
- see above
Doses / concentrations
- Dose / conc.:
- 32 mg/L air (analytical)
- Remarks:
- Basis:
analytical conc.
- No. of animals per sex per dose:
- 6 animals per dose
- Control animals:
- no
- Details on study design:
- - Dose selection rationale: based on result of acute inhalation study
- Positive control:
- none
Examinations
- Observations and examinations performed and frequency:
- CLINICAL OBSERVATIONS: Yes
BODY WEIGHT: No data
FOOD CONSUMPTION: No data
WATER CONSUMPTION: No data
OPHTHALMOSCOPIC EXAMINATION: No data
HAEMATOLOGY and CLINICAL CHEMISTRY: No
URINALYSIS: No
NEUROBEHAVIOURAL EXAMINATION: No - Sacrifice and pathology:
- GROSS PATHOLOGY: Yes (no further data)
HISTOPATHOLOGY: Yes (no further data) - Statistics:
- none
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Description (incidence and severity):
- discomfort
- Mortality:
- mortality observed, treatment-related
- Description (incidence):
- discomfort
- Details on results:
- Pathological Changes:
1 rat killed day of 9th treatment - slight emphysema
1 rat killed 11 days after 9th treatment - bronchopneumonia possibly aggravated by exposure
Effect levels
- Key result
- Dose descriptor:
- conc. level:
- Effect level:
- ca. 32 mg/L air
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- other: Only one dose level tested; Discomfort; effects in lung noted in 2/6 animals (pulmonal irritation but no systemic effects).
- Remarks on result:
- other: Repeated inhalation of massive amounts of dust may be a source of pulmonary irritation.
Target system / organ toxicity
- Key result
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Repeated inhalation of an extremely high concentration of SIM-Ester in its dust form (32 mg/L) resulted in adverse effects in the respiratory tract.
- Executive summary:
In a repeated dose inhalation toxicity study (Haskell Laboratory for Toxicology and Industrial Medicine, 1959) 6 ChR-CD rats were whole body exposed to SIM-Ester dust 4 hours per day for 9 days during a period of two weeks. The test concentration was 32 mg/L (+/- 20%); 75% of the particles had a diameter below or equal to 3 µm. Amimals showed discomfort. Treatment related effects were limited to a slight emphysema seen in one animal (sacrificed on the 9th treatment day) and bronchopneumonia observed in another animal (sacrificed 11 days after the 9th treatment). No further pathologcial changes were reported. The authors concluded that repeated inhalation of massive amouts of SIM-Ester in its dust form may be a source of pulmonary irritation. This is most likely due to the dust overload effect and not related to the intrinsic properties of the substance.
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