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EC number: 202-088-8 | CAS number: 91-66-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
PBT assessment
Administrative data
PBT assessment: overall result
- Name:
- N,N-diethylaniline
- Type of composition:
- legal entity composition of the substance
- State / form:
- liquid
- Reference substance:
- N,N-diethylaniline
- PBT status:
- the substance is not PBT / vPvB
- Justification:
Classification of N, N-diethylaniline for effects in the environment:
The chemical N, N-diethylaniline (CAS no. 91-66-7) is used in the synthesis of pharmaceuticals and dyes. It is also used for other organic synthesis.The aim was to assess whether the PBT criterion within Annex XIII was fulfilled forN, N-diethylaniline.The PBT criterion was herein assessed based on experimental data in conjunction with standardized environmental fate models. Here follows a description of the PBT assessment.
Persistence assessment
The tested substance fulfils the P criterion within Annex XIII based on the assessment that here follows:
Biotic degradation
The first experimental study have been reviewed from authoritative database (J-check) in this study the test chemical was subjected to biodegradation test by taking sludge as inoculums at 30 mg/L concentration. Biodegradation was analyzed by using two parameters that are BOD and TOC. The initial concentration of test chemical was 100 mg/L and study design was of standard type. After 2 weeks test chemical showed 0.0%, and 1.0 % degradation by BOD and parameter respectively in two weeks (14 days).On the basis of % degradation values it is concluded that test chemical is not readily biodegradable.
Next study was reviewed from Sewage and Industrial Wastes journal (1955) in this study the biodegradation experiment was performed by using to OECD test guideline 301C. The percent degradation of test chemical was determined to be 0.0% in 14 days by using activated sludge as inoculum. On the basis of percent degradation value it is concluded that test chemical is not readily biodegradable in nature.
Another study was reviewed from secondary source in this study the percent biodegradation of test chemical was determined to be 0.0% by using BOD as parameter and sewage as inoculums in 5 days at 20⁰C. On the basis of percent degradation value it is concluded that test chemical is not readily biodegradable in nature.
Thus, based on the available information, it indicates thatchemicalN, N-diethylanilinecan be considered to be not readily biodegradable in water and thus likely to be persistent (P) in nature.
Bioaccumulation assessment
The tested substance does not fulfil the B criterion within Annex XIII based on the assessment that here follows:
The BCF value from authoritative databases was determined to be 16 to 161 dimensionless, respectivelyand the octanol water partition coefficient of the test chemical was determined to be 3.90, respectively, which is less than the threshold of 4.5. If this chemical is released into the aquatic environment, there should be a low risk for the chemical to bioaccumulate in fish and food chains.
Toxicity assessment
The tested substance fulfils the T criterion within Annex XIII based on the assessment that here follows:
Mammals
The tested chemical is regarded to be not classified for carcinogenicity, mutagenicity and reprotoxicity,
Further, there is evidence of chronic toxicity, as identified by the classifications STOT (repeated exposure), in ‘Category 2’ (oral, dermal, inhalation of gases/vapours, inhalation of dust/mist/fume) as per the CLP Regulation.
Aquatic organisms
All of the available short-term eco-toxicity data for fish, invertebrates and algae for the substanceN, N-diethylanilineindicates the LC50/EC50 value to be in the range 2.8 to 42.25 mg/L, respectively. Whereas on the basis ofthelong term eco-toxicity data for fish and aq. Invertebrates, the NOEC value was evaluated to be ranges from 0.936 to 1.252 mg/l, respectively. These value suggest that the substance is likely to be hazardous to aquatic organisms at environmentally relevant concentrations and can be considered to be classified in ‘Aquatic chronic category 2’ as per the CLP regulation.
By speculation, long-term NOEC for aquatic organisms were not expected for the substance at concentration below 0.01 mg/L based on the data mentioned above.
The chemical was therefore not considered as hazardous to aquatic environments as per the criteria set out in Annex XIII.
Conclusion
Based on critical, independent and collective evaluation of information summarized herein, the tested compound fulfils the P and T criterion, but does not fulfil the B criterion and has therefore not been classified as a PBT compound within Annex XIII.
Reference
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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