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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 914-103-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP - Guideline study (Adopted according to OECD SIDS)
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EPA 540/9-82-025
- GLP compliance:
- yes
- Type of study:
- guinea pig maximisation test
Test material
- Reference substance name:
- Ammonium chloride
- EC Number:
- 235-186-4
- EC Name:
- Ammonium chloride
- Cas Number:
- 12125-02-9
- IUPAC Name:
- ammonium chloride
- Details on test material:
- - Name of test material (as cited in study report): Ammonium chloride (Hoechst)
- Physical state: crystalline
- Analytical purity: 99.1%
- Other: white
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- other: Pirbright-White
- Sex:
- female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: breeder
- Age at study initiation: about 8 weeks
- Mean weight at study initiation: 240 g
ENVIRONMENTAL CONDITIONS: not reported
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- other: 1st: intracutaneous, 2nd: occlusive epicutaneous
- Vehicle:
- other: 0.9% NaCl solution
- Concentration / amount:
- 1st Induction: 5%, 2nd Induction 25 %, 3rd: Challenge: 10 %.
Challengeopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- other: 0.9% NaCl solution
- Concentration / amount:
- 1st Induction: 5%, 2nd Induction 25 %, 3rd: Challenge: 10 %.
- No. of animals per dose:
- 20
- Details on study design:
- MAIN STUDY
A. INDUCTION EXPOSURE
1st application: Induction 5 % intracutaneous
2nd application: Induction 25 % occlusive epicutaneous
B. CHALLENGE EXPOSURE
3rd application: Challenge 10 % occlusive epicutaneous
METHOD
Day 1 : Intradermal induction exposure (Injection): The injection sites were not covered.
Day 1-7: The application area was investigated.
Day 9 : Dermal induction exposure: 0.5ml of the test substance preparation were applied to a cellulose patch of 2x4 cm. This patch covered
the area of the intradermal injection sites. An occlusive dressing with impermeable foil and an elastic bandage sealed the application site for 48 hours.
Day 11 : Removal of the occlusive dressing. Recording of the irritation.
Day 22 : Dermal challenge exposure. 0.5ml of test substance preparation were applied to a cellulose patch and placed onto the clipped skin of the flank. An occlusive dressing with impermeable foil and an elastic bandage sealed the application site for 24 hours.
Day 23 : Removal of the occlusive dressing.
Day 24-25: Assessment of the skin.
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- other: 1st and 2nd reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- ca. 76.5 mg (10%)
- No. with + reactions:
- 2
- Total no. in group:
- 20
- Clinical observations:
- No signs of toxicity; 24 and 48 hours after removal of the occlusive dressing, very slight, hardly perceptible erythema
- Remarks on result:
- other: see Remark
- Remarks:
- Reading: other: 1st and 2nd reading. . Hours after challenge: 24.0. Group: test group. Dose level: ca. 76.5 mg (10%). No with. + reactions: 2.0. Total no. in groups: 20.0. Clinical observations: No signs of toxicity; 24 and 48 hours after removal of the occlusive dressing, very slight, hardly perceptible erythema .
Any other information on results incl. tables
1) The treated animals did not show any signs of toxicity throughout the study period.
2) Induction: Very slight to slight edema were observed in the treatment group.
3) Challenge: 24 and 48 hours after removal of the occlusive dressing, a total of 2 animals (in 20) of the treatment group showed very slight, hardly perceptible erythema.
Ten percent of the animals of treatment group demonstrated a positive reaction after the challenge exposure (the criteria: the limit value of 30 percent).
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
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