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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 200-929-3 | CAS number: 76-05-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
A key study performed under OECD guideline 203 with GLP shows no toxicity on Danio rerio and gives an LC50 (96h) > 999 mg/L and a NOEC (96h) of 999 mg/L Trifluoroacetic acid. A supporting study performed under an ISO guideline gives a NOEC (96h) > 8000 mg/L on the same species.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- LC50
- Effect concentration:
- > 999 mg/L
Additional information
The key study for short term toxicity to fish was performed with Trifluoroacetate sodium on the freshwater fish, Danio rerio under static conditions for 96h according to OECD Guideline 203 and GLP (Groeneveld, 1992). All validity criteria were fulfilled, this study was reliable without restriction. The study is a limit test at 1200 mg/l of Trifluoroacetate sodium in duplicates (i.e. 999 mg/l of Trifluoroacetic acid, TFA) with control. No mortality was observed so the LC50 (96h) was determined as greater than 999 mg/l and the NOEC is equal to 999 mg/l of TFA.
An other 96h-acute toxicity study was performed, according to NF ISO 7346 -1, with Trifluoroacetic acid on the same species under static conditions (Barthel, 2008). A limit test was realized at 8000 mg/L of TFA with control. No mortality was observed after 96 hours therefore a NOEC (96h) greater than 8000 mg/L was derived. However, some critical information on the substance purity, the test conditions and results is missing in the report to consider this study as reliable. Therefore these results are used as supportive information.
The key value used for chemical safety assessment is an LC50 greater than 999 mg/L of Trifluoroacetic acid for short term toxicity on freshwater fish.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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