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Diss Factsheets
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EC number: 206-370-1 | CAS number: 333-20-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The study was performed pre-GLP and pre-guideline. The paper considers the kinetics of elimination of thiocyanate, firstly in healthy subjects with normal and with raised levels of chloride intake, and secondly in subjects with renal failure.
Data source
Reference
- Reference Type:
- publication
- Title:
- Kinetics of elimination of thiocyanate in 7 healthy subjects and in 8 subjects with renal failure.
- Author:
- Schulz, V. Bonn, R. Kindler, J.
- Year:
- 1 979
- Bibliographic source:
- Klin Wochenschr. Vol 57, Issue 5, pp 243-7
Materials and methods
- Objective of study:
- excretion
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- Potassium thiocyanate
- EC Number:
- 206-370-1
- EC Name:
- Potassium thiocyanate
- Cas Number:
- 333-20-0
- Molecular formula:
- CNS.K
- IUPAC Name:
- potassium thiocyanate
- Details on test material:
- KSCN
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- human
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: unspecified
Results and discussion
Any other information on results incl. tables
The initial concentration of the SCN- in the serum. (by extrapolation) was on average 39 mg/l and 38 mg/1 for the tests with and without NaCl loading, respectively. The apparent distribution volume (Vd) had a mean value of 0.25 l/ kg, or 25% of the body volume. The mean half-life (t1/2) of the thiocyanate was lowered by only 15% from 2.7 to 2.3 days by the NaCl loading. The half-life values in the serum showed a relatively wide scatter for the seven subjects (1.5 to 5 days approx.). The renal thiocyanate-clearance (Clr) had a mean value of 5.65 ml/min with and 4.32 ml/min without the NaCl loading. The basic excretion rate of thiocyanate (UEb) was 23±5 mg/d. Of the amounts administered as doses, 102% (UE%) was found to be the total collected in the urine over fourteen days, after subtracting to allow for the basic excretion. In the subjects with renal failure t he mean creatinine-clearance was 22 ml/min. The mean distribution volume (Vd) was 0.36 l/kg, i.e. higher than in the healthy subjects. The mean elimination half-life (t1/2) was 9 days, i.e. 3 times longer than in the healthy subjects.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
The study has many limitation but the results suggest that there no bioaccumulation occurs. - Executive summary:
The concentration of thiocyanate in the serum of eight test subjects with renal failure and seven healthy control subjects was measured, as it declined with time, after oral doses of thiocyanate or i.v. injections of nitroprusside had been administered. Additional measurements were taken, on the healthy subjects only, of the concentrations of thiocyanate in the urine. and also of the influence of an increased chloride intake on the rate of eliminiation of thiocyanate. For the healthy subjects an elimination half-life of between one and five days (mean c. 3 days) was found. Increasing the chloride elimination rate to approximately twice normal did not significantly speed up the rate of thiocyanate elimination. The amounts of thiocyanate which had been administered as doses reappeared almost exclusively in the urine. For the subjects with renal failure, the elimination half-life had a mean value of approximately nine days. The elimination constants were found to be proportional to the creatinine-clearance rates. The ke value at a creatinine-clearance of zero ml/min was approximately 15% of the ke, value at a creatinineclearance rate of 120 ml/min. The distribution volumes for thiocyanate were greater for the patients with renal failure than for the healthy subjects. The conclusions for therapies using nitroprusside are discussed.
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