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EC number: 407-330-8 | CAS number: 61571-06-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- - Name of test material (as cited in study report): 3.4.5.6-Tetrahydro-2H-Thiopyran-3-Carboxyaldehyd
- Substance No.: 84/0242
- Analytical purity: 98 %
- no further data
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr. K. Thomae GmbH, Biberach, Germany
- Age at study initiation: young adults
- Weight at study initiation: Animals of comparable weight (+/- 5 % of mean weight)
- Fasting period before study: 16 hours
- Housing: 5 per cage in stainless steel cages
- Diet: Kliba-Labordiaet, Klingenthalmuehle AG, Kaiseraugst, Switzerland ad libitum
- Water: Tap water ad libitum
- Acclimation period: at least 8 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24
- Humidity (%): 30-70
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 0.5 % CMC in water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 50.0; 38.3; 26.1; 17.8, 12.1 %, respectively
- Amount of vehicle (if gavage): 10 ml/kg bw
- Justification for choice of vehicle: aqueous formulation corresponds to the physiological medium
MAXIMUM DOSE VOLUME APPLIED: 10 ml/kg bw - Doses:
- 5000, 3830, 2610, 1780, 1210 mg/kg bw
- No. of animals per sex per dose:
- 5 males and 5 females per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Recording of signs and symptoms several times on the day of administration at least once each workday; check for moribund and dead animals twice each workday and at least once on weekends and public holidays
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 3 120 mg/kg bw
- 95% CL:
- 2 270 - 4 100
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 4 520 mg/kg bw
- 95% CL:
- 3 620 - 8 510
- Mortality:
- males: 1/5 in the highest dosing group
females: 5/5 in the highest dosing group, 3/5 in the 3830 mg/kg dose group and 2/5 of the 2610 mg/kg dose group
no other deaths occurred - Clinical signs:
- male animals: dyspnoea, staggering, apathy, piloerection, exsiccosis, diarrhea, blood in urine, poor general state from day returning to normal within 2 days in surviving animals
female animals: dyspnoea, staggering, abnormal position, atonia, apathy, piloerection, paresis, pain reflex absent, corneal reflex absent, narcotic-like state, exsiccosis, diarrhea, blood in urine, poor general state from day returning to normal within 2 days in surviving animals - Body weight:
- nothing abnormal detected
- Gross pathology:
- Animals that died (male and female):
General congestive hyperemia.
Stomach: isolated cases atonic and empty.
Glandular stomach: reddened.
Intestine: empty and atonic.
Urinary bladder: 1 female animal: questionable bloody ulcerations.
Histopathology of 1 animal that died (female, 5000 mg/kg):
Kidneys: tubulonephrosis and hyperemia.
Urinary bladder: hemorrhages.
Sacrificed animals (male and female):
1210 - 1780 mg/kg:
Organs: no abnormalities detected.
2610 - 5000 mg/kg:
Forestomach: slight thickening of the wall, up to distinctly intensified focal thickening.
Histopathology of 1 sacrificed animal at the end of the study (male, 5000 mg/kg):
Forestomach: partly hyperkeratotic area, partly cicatrized ulcer.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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