Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Density
Administrative data
- Endpoint:
- density, other
- Remarks:
- Relative density
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2021-02-01 to 2021-07-14
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 021
- Report date:
- 2021
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.3 (Relative Density)
- Version / remarks:
- March 04, 2016
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 109 (Density of Liquids and Solids)
- Version / remarks:
- October 2, 2012
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7300 (Density / Relative Density / Bulk Density)
- Version / remarks:
- June 2002
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- air comparison pycnometer (for solids)
Test material
- Reference substance name:
- 1-[2-[2-methoxy-4-(morpholin-4-yl)-5-nitroanilino]pyrimidin-4-yl]-3-phenyl-1H-pyrazole-4-carbaldehyde
- Cas Number:
- 1903010-39-8
- Molecular formula:
- C25H23N7O5
- IUPAC Name:
- 1-[2-[2-methoxy-4-(morpholin-4-yl)-5-nitroanilino]pyrimidin-4-yl]-3-phenyl-1H-pyrazole-4-carbaldehyde
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Physical state: solid
- Appearance: orange powder
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Batch (Lot) Number: I20ED2016
- Purity/Composition: 101.5%
- Purity test date : 2020-05-27
- Expiry date: 2022-06-06 (retest date)
- Physical Description: Orange powder
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: At room temperature
- Stability and homogeneity of the test material in the vehicle/solvent under test conditions and during storage: not indicated
- Stability in the medium, i.e. sensitivity of the test material to hydrolysis and/or photolysis: not indicated
- Solubility and stability of the test material in the solvent/vehicle and the exposure medium: not indicated
- Reactivity of the test material with the incubation material used (e.g. plastic ware): not indicated
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Final preparation of a solid: prior to use in the study, the test material was dried in a desiccator under vacuum using silicagel as the drying agent at 18.0 ± 2.6°C in dark for 49.9 hours.
OTHER SPECIFICS
- Purity/Composition correction factor: Yes, correction factor is 1.0
Results and discussion
Densityopen allclose all
- Key result
- Type:
- density
- Density:
- 1.37 g/cm³
- Temp.:
- 20 °C
- Type:
- relative density
- Density:
- 1.37
- Temp.:
- 20 °C
Any other information on results incl. tables
The results of the tests on the determination of the density of the test item are given in the table below
| Test 1 | Test 2 | Test 3 | |
| Density [g/cm3] | 1.373 | 1.373 | 1.37 |
The individual measurements were obtained with an accuracy of < 0.02 g/cm3. According to the guideline, the density of the test item is given as the mean value.
Applicant's summary and conclusion
- Conclusions:
- A gas comparison stereopycnometer was used for the determination of the density and relative density of JNJ-73848255-AAA (T003902).
The density of the test item at 20ºC was 1.37 g/cm3 (1.37 x E3 kg/m3).
The relative density was 1.37.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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