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EC number: 618-311-0 | CAS number: 898543-06-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Mar 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- 2004
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Vehicle:
- no
- Details on test solutions:
- PRETREATMENT OF TEST ITEM:
- 105.3 mg of the test item added to 1 L of dilution water and treated for 1 h in an ultrasonic bath. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Daphnia magna STRAUS, parthenogenetic females, strain of Bundesgesundheitsamt Berlin
Maintenance and Acclimatisation:
A population of parthenogenetic females of synchronized age structure has been maintained for more than 15 years in the test facility under constant temperature conditions (20 +/- 1 °C) at a 16 : 8 hour light-dark photoperiod (illumination > 1000 lux). The culture water (so-called 'M4 medium') was partly renewed once a week. The Daphnia were exclusively fed unicellular green algae (Desmodesmus subspicatus) 'ad libitum'. Mortalities of parent Daphnia during the culture period were recorded daily in a semi-quantitative way. The neonates were separated from their parent Daphnia by filtration prior to the acute test. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- 16.0 °dH (= 286 mg/L CaCO3)
- Test temperature:
- 20.6 °C after 48 h
- pH:
- 7.9 after 48 h
- Dissolved oxygen:
- 8.5 mg/L after 48 h
- Nominal and measured concentrations:
- 100 mg/L (nominal) plus control
Results of analysis of test substance concentration (0 and 100 mg/l) in test solutions at 0 and 48 h showed that the substance stayed stable through the test duration (Measured concentrations were in range of 101.5 - 102.8% of nominal concentrations). - Details on test conditions:
- TEST SYSTEM:
- Test vessels: 50 mL glass beakers covered with watch glass holding 20 mL of test solution
- 1 test concentrations (100 mg/L) plus 1 control
- 10 neonates per vessel, 2 replicates per concentration/control
- Temperature of incubation unit : 18-22 °C
- No feeding during the exposure period
- Photoperiod: 16 h light: 8 h dark
- No aeration
- Medium renewal: none
- Criteria of effects: item-induced alteration of the normal mobility behaviour and the loss of locomotory actions of the neoates, observed at 24 and 48 h. - Reference substance (positive control):
- no
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- Recovery rates correspond to 102.8% of nominal values at 0 hours, and to 101.5% of nominal values at 48 hours, respectively.
- Validity criteria fulfilled:
- yes
- Remarks:
- (The immobilisation and other abnormalities in the controls did not exceed 10% by the end of the test. - The dissolved oxygen concentration remained above 3 mg/L throughout the exposure period.)
- Conclusions:
- EC50 (48 h) > 100 mg/L (nominal)
- Executive summary:
In order to test acute toxicity to invertebrates of the substance, Daphnia magna was exposed to a limit concentration of 100 mg/L and a blank control solution for a period of 48 h under static conditions. Mobility and visible abnormalities were recorded at 24 and 48 h. The measured concentrations confirmed that deviation from the nominal concentrations was less than 20% . No toxic effect and abnormal behavior were observed. Thus, an EC50 (48 h) of > 100 mg/L was derived.
Reference
Description of key information
Daphnia Magna was exposed under static conditions for 48 h to one concentration (100 mg/L) of 3-Morpholinone, 4-[4-[(5S)-5-(aminomethyl)-2-oxo-3-oxazolidinyl]phenyl]-, hydrochloride. No toxic effect was observed.
Key value for chemical safety assessment
Additional information
No toxic effects could be determined for 3-Morpholinone, 4-[4-[(5S)-5-(aminomethyl)-2-oxo-3-oxazolidinyl]phenyl]-, hydrochloride in the acute toxicity test for Daphnia.
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