Registration Dossier
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Diss Factsheets
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EC number: 601-143-7 | CAS number: 111974-69-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Administrative data
First-aid measures
Remove contaminated clothing. In case of loss of knowledge put the person in the safe position and transport the person to the fresh air. Rescuers have to worry primarily about their protection.
Inhalation: Move the affected person from the area and make it stretch, if breathing is difficult, give oxygen, if breathing is absent use mechanical ventilation. Consult a physician if symptoms appear.
Ingestion: Do not induce vomiting unless on the advice of medical personnel, in case of vomiting tilt the patient forward or put it on the side with head facing down to keep the airways open and prevent aspiration.Don’t give anything by mouth to people who give signs of drowsiness or numbness, or who are about to lose consciousness. Consult a physician if symptoms appear
Skin Contact: Remove contaminated clothing and wash thoroughly with water. Consult a physician if symptoms appear.
Eyes contact: Wash immediately with plenty of water for at least 15 minutes taking care to keep the eyelids separated the eye, contact lens should be removed only by experienced personnel. Consult a physician if symptoms appear.
Fire-fighting measures
Suitable extinguishing media: Water spray, foam, dry chemical, carbon dioxide.
Special hazards arising from the substance or mixture: When heated to decomposition or under fire conditions it could be emitted toxic fumes like carbon monoxide or other typical organic combustion products
Advice for firefighters: Fire fighters should use self-contained breathing apparatus and protective clothing. As the substance, when exposed to thermal irradiation or directly involved in a fire, may produce toxic fumes, if it is safe to do, remove the containers from the fire area or keep containers cool.
Damaged containers must be handled only by authorized trained personnel.
Extinguish flames at a safe distance from the containers, by using fire hoses or
extinguishers automatic systems with nozzles positioned at the top of the containers.
Accidental release measures
Personal precautions, protective equipment and emergency procedures:
Evacuate from affected area the personnel not involved in emergency intervention. Avoid dust formation. Avoid breathing vapors, mist or gas.
Environmental precautions:
Do not let product enter drains.
Methods and material for containment and cleaning up
Small Losses:
Remove any source of ignition, stopping the source of the spillage, avoid contact with skin or inhalation, use PPE, clean up immediately using adsorbent materials. Collected material should be placed in proper container, labeled and sent to for final disposal
Large losses:
Report immediately the incident and remove of unnecessary personnel from the area. Stop the spread and isolate the spilled material; Isolate sewers discharging to superficial waters and/or segregate any water runoff into collection basins or tanks to facilitate processing or disposal.
The personnel involved in containment and cleaning should wear appropriate personal protective equipment to minimize exposure. The area must be thoroughly cleaned using adsorbent materials. Collected material should be placed in proper container, labeled and sent to for final disposal
Handling and storage
The substance is used under strictly controlled conditions during its whole lifecycle as described under Reach, Article 17. The substance is rigorously contained by technical means during its whole lifecycle and procedural and control technologies are used to minimise emission and any resulting exposure .
Handling: Wear suitable protective clothing, gloves and eye/face protection (musk included).
Storage: Store in a cool and well ventilated place. Keep container tightly closed, properly labelled. Keep away from source of ignition, no smoking.
Avoid release to the environment.
Prevent contact with possible ignition sources; avoid contact with eyes, skin and clothing. Remove contaminated clothes and wash thoroughly after handling. Do not eat, drink, and smoke in work areas.
Use container tightly closet and resistant, away from moisture and sunlight. Avoid contact with air and light. Properly label containers in case of pouring and clean external container surfaces with proper detergents and /or solvents.
Transport information
Land transport (UN RTDG/ADR/RID)
- UN number:
- 3077
Shipping information
- Proper shipping name and description:
- ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S.
- Chemical name:
- Quetiapine fumarate
- Class or division:
- Class 9: Miscellaneous dangerous substances and articles, including environmentally hazardous substances
- Packing group:
- Packing group III: Substances presenting low danger
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Marine transport (UN RTDG/IMDG)
- UN number:
- 3077
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Air transport (UN RTDG/ICAO/IATA)
- UN number:
- 3077
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Exposure controls / personal protection
Use protective mask with P2 or P3 type dust filter (EN 143). If the substance is dissolved in organic solvent and manipulated in an open environment in significant quantities use an appropriate filter for chemicals (A type for boiling temperature > 65°C or Ax type for boiling temperature < 65°C) or ABEK type if simultaneous presence of others substances like, inorganic vapors, ammonia, etc. (EN 14387).
Protection for eyes / face:
For dry product use safety glasses goggles. For the wet product use face shield or other full-face protection if it is required also airways protection. If semi-mask is in use for the protection of the airways use safety glasses googles as in the case of the dry product.
Protection for skin / hands:
Use chemical resistant gloves (EN374) with material compatible with solvent in which the
substance is dissolved; the actual permeation time through the gloves and their life can be
affected by mode of use, temperature and substance quantities handled.
Other protection:
In production or packaging plants is recommended full-body suite like Tyvek® type, protection against liquid aerosols Type 4 (EN 14605) resistant to penetration by solid particles sprayed Type 5 (EN 13982-1), low intensity sprays Type 6 (EN 13034 and EN 17491) and antistatic (EN 1149).
Technical controls and ventilation:
In Production or re-packaging plants: use general ventilation systems, or closed systems to ensure the isolation of the substance from the working personnel. Can be provided additional safety controls according to specific “control band” and the specific Exposure Control Matrix established for the substance.
Laboratory: It’s always recommended to use fume cupboard or cabinet.; Can be provided additional safety controls according to specific “control band” and the specific Exposure Control Matrix established for the substance.
Stability and reactivity
No dangerous reaction known under conditions of normal use.
As a precautionary measure, keep away from heat sources and electrostatic
discharges Avoid conditions which create dust.
Incompatible materials: Strong oxidizing agents, strong acids, strong bases.
Hazardous decomposition products: Thermal decomposition may produce toxic vapours of carbon dioxides in case of partial combustion and other typical combustion products of organic materials
Disposal considerations
Dispose of waste in accordance with all applicable laws and regulations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.