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EC number: 428-790-6 | CAS number: 72963-72-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- January 4 - February 21, 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 425 (Acute Oral Toxicity: Up-and-Down Procedure)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- up-and-down procedure
Test material
- Reference substance name:
- -
- EC Number:
- 428-790-6
- EC Name:
- -
- Cas Number:
- 72963-72-5
- Molecular formula:
- C17H22N2O4
- IUPAC Name:
- [2,5-dioxo-3-(prop-2-yn-1-yl)imidazolidin-1-yl]methyl (1R,3R)-2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropane-1-carboxylate; [2,5-dioxo-3-(prop-2-yn-1-yl)imidazolidin-1-yl]methyl (1R,3S)-2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropane-1-carboxylate
- Test material form:
- liquid: viscous
- Details on test material:
- Name: Imiprothrin
Appearance: viscous liquid
Colour: amber
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Number of Animals: 9
Sex: Female, nulliparous and non-pregnant.
Age/Body Weight: Young adult (9-12 weeks)/193-208 grams at experimental start.
Animal Room Temperature and Relative Humidity Ranges: 19-23ºC and 39-60%, respectively.
Animal Room Air Changes/Hour: 13. Airflow measurements are evaluated regularly and the records are kept on file at Product Safety Labs.
Photoperiod: 12-hour light/dark cycle
Acclimation Period: 13-28 days
Food: ad libitum, except during fasting.
Water: Filtered tap water was supplied ad libitum.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- Based on a limit dose of 5000 mg/kg, a Main Test was conducted using a default starting dose level of 175 mg/kg which was administered to one healthy female rat by oral gavage. Following the Up and Down procedure, eight additional animals were dosed at levels of 175, 550, 1750, or 5000 mg/kg.
- Details on study design:
- The animals were observed for mortality, signs of gross toxicity, and behavioral changes approximately 30 minutes post-dosing, during the first several hours post-dosing and at least once daily thereafter for 14 days after dosing or until death occurred. Observations included gross evaluation of skin and fur, eyes and mucous membranes, respiratory, circulatory, autonomic and central nervous systems, somatomotor activity and behavior pattern. Particular attention was directed to observation of tremors, convulsions, salivation, diarrhea, and coma.
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 750 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 651.9 - < 2 690
- Mortality:
- 1750 mg/kg Dose Level (4 animals): three animals died within six hours of test substance administration. Prior to death, the animals exhibited irregular respiration and tremors.
5000 mg/kg Dose Level (1 animal): the animal died within two hours of test substance administration. Prior to death, the animal exhibited irregular respiration and tremors. - Gross pathology:
- 175 mg/kg Dose Level (1 animal): No gross abnormalities were noted for the animal when necropsied at the conclusion of the 14-day observation period.
550 mg/kg Dose Level (3 animals): No gross abnormalities were noted for these animals when necropsied at the conclusion of the 14-day observation period.
1750 mg/kg Dose Level (4 animals): Gross necropsy of the decedents revealed distention of the stomach and/or intestines and a liquid filled stomach. No gross abnormalities were noted for the surviving animal when necropsied at the conclusion of the 14-day observation period.
5000 mg/kg Dose Level (1 animal): Gross necropsy of the decedent revealed a liquid filled and distended stomach and distended intestines. - Other findings:
- 175 mg/kg Dose Level (1 animal): the animal survived exposure to the test substance, gained body weight, and appeared active and healthy during the study. There were no signs of gross toxicity, adverse clinical effects, or abnormal behavior.
550 mg/kg Dose Level (3 animals): all animals survived exposure to the test substance and gained body weight during the study. Following administration, one animal exhibited irregular respiration, reduced fecal volume and hypothermia. However, the animal recovered by Day 2 and along with the remaining two animals appeared active and healthy for the remainder of the 14-day observation period.
1750 mg/kg Dose Level (4 animals): following administration, the surviving animal was hypoactive and exhibited irregular respiration and reduced fecal volume. However, the surviving animal recovered by Day 2 and appeared active and healthy for the remainder of the 14-day observation period, gaining body weight over the course of the study.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Under the conditions of this study, the acute oral LD50 of the test substance is estimated to be 1750 mg/kg of body weight (based on the one dose with a partial response and an assumed sigma of 0.5) in female rats with a 95% PL 1confidence interval of 651.9 mg/kg (lower) to 2690 mg/kg (upper).
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