Registration Dossier
Registration Dossier
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EC number: 228-207-3 | CAS number: 6168-72-5
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 5 September 2017 to 16 February 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
Test material
- Reference substance name:
- DL-2-aminopropan-1-ol
- EC Number:
- 228-207-3
- EC Name:
- DL-2-aminopropan-1-ol
- Cas Number:
- 6168-72-5
- Molecular formula:
- C3H9NO
- IUPAC Name:
- 2-aminopropan-1-ol
1
Results and discussion
Water solubilityopen allclose all
- Water solubility:
- >= 50 - <= 100 g/L
- Conc. based on:
- test mat. (dissolved fraction)
- Remarks:
- Visual observation of dissolution in preliminary test.
- Temp.:
- 20 °C
- Remarks on result:
- other: pH not measured
- Key result
- Water solubility:
- 641.8 g/L
- Conc. based on:
- test mat. (total fraction)
- Remarks:
- Analytical results
- Temp.:
- 20 °C
- pH:
- > 13.1 - < 13.2
Applicant's summary and conclusion
- Executive summary:
The water solubility at 20°C was:
- In a preliminary test with only 10-minute agitation between water additions: 49.92-99.85 g/L by visual observation.
- In the definitive test with extensive centrifugation and shaking: 641.8 g/L as the mean from analytical measurements (LC-MS/MS) at pH 13.1-13.2.
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