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Diss Factsheets
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EC number: 241-221-4 | CAS number: 17169-60-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- STRUCTURAL DETERMINANTS IN THE OXIDATION OF ALIPHATIC COMPOUNDS BY ACTIVATED SLUDGE
- Author:
- Malaney GW, Gerhold RM
- Year:
- 1 969
- Bibliographic source:
- Journal (Water Pollution Control Federation), vol. 41, no. 2, 1969, pp. R18–R33. www.jstor.org/stable/25036256.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - Principle of test:
Determination of oxygen uptake/oxidation of the compound using the Warburg respirometer
- Short description of test conditions:
Exposure of individual chemical compounds at a concentration of 500 mg/L to activated sludge solids at 2,500 mg/L in the Warburg respirometer with oxygen uptake as the measure of oxidation of the compound. The theoretical oxygen demand (TOD) is defined as the concentration of oxygen in mg/L required to oxidize 500 mg/L of substrate completely, i.e., to CO2, water, nitrate, sulfate, and chlorate. - GLP compliance:
- no
Test material
- Reference substance name:
- Glycine
- EC Number:
- 200-272-2
- EC Name:
- Glycine
- Cas Number:
- 56-40-6
- Molecular formula:
- C2H5NO2
- IUPAC Name:
- aminoacetic acid
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Duration of test (contact time):
- 24 h
Initial test substance concentration
- Initial conc.:
- 500 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Remarks:
- percent from TOD
Reference substance
- Reference substance:
- other: no
Results and discussion
% Degradation
- Key result
- Parameter:
- % degradation (O2 consumption)
- Remarks:
- percent of TOD
- Value:
- 16.9
- Sampling time:
- 24 h
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not applicable
- Interpretation of results:
- readily biodegradable
- Conclusions:
- In the present study of Malaney and Gerhold the biological oxygen demand, i.e. the concentration of oxygen in mg/L required to oxidize 500 mg/L of substrate completely, of activated sludge incubated with glycine was determined. The result reveals that 16.9 % of the compound were degraded within 24 h, therefore glycine is less susceptible to oxidation than the other amino-acids investigated but considered readily biodegradable because it belongs to the same chemical family as the amino acids that are more susceptible to oxidation.
- Executive summary:
In the study of Malaney (1969) the biological oxygen demand of activated sludge incubated with glycine was determined. Again, this study was conducted prior to implementation of standard guidelines and GLP. The study was reported in sufficient detail and provides evidence that glycine is readily biodegradable. The result reveals that 16.9 % of the compound were degraded within 24 h, therefore glycine is less susceptible to oxidation than the other amino-acids investigated but considered readily biodegradable because it belongs to the same chemical family as the amino acids that are more susceptible to oxidation.
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