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EC number: 221-656-6 | CAS number: 3179-31-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,2,4-triazole-3-thiol
- EC Number:
- 221-656-6
- EC Name:
- 1,2,4-triazole-3-thiol
- Cas Number:
- 3179-31-5
- Molecular formula:
- C2H3N3S
- IUPAC Name:
- 4H-1,2,4-triazole-3-thiol
- Test material form:
- solid: crystalline
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Himalayan
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0,1g
- Duration of treatment / exposure:
- one time application
- Observation period (in vivo):
- 13 days a.appl.
- Number of animals or in vitro replicates:
- 1 (one male, two females)
- Details on study design:
- 0.1 g of the test substance was placed in the conjunctival sac of the right eye.Then both lids were kept closed for a short time by light finger pressure.The left eye of each animal was left untreated and served as a control. The treated eye was not rinsed.
obersvation tome point: 1, 24, 72 hours, after that ones daily till day 13.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 2d
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 4d
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- 24/48 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 3d
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 48 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 6d
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 6d
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 6 d
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72h
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 13 d
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 13 d
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 13d
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 13d
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 13d
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- After the individual introduction of 0.1 g test substance into the conjunctival sac of 3 rabbits, changes occurred in the cornea, iris and conjunctiva. After application of the test substance, the cornea showed slight diffuse turbidity (rating number 1) or details of the iris were slightly shaded due to the clouding (rating number 2). The turbidity zone covered almost the entire corneal area in all animals. On the 6th day of observation, these changes had subsided. The iris showed moderate circular corneal hyperemia during the first three days of observation (rating number 1). The conjunctiva reacted in all animals with diffuse flesh-colored redness (rating number 3). In addition, there was significant swelling, which led to the partial turning of the lids or to half-closed lids (rating number 3). Redness was longest until 13th observation day demonstrable. Hypersecretion, which moistened the eyelids and hair or considerable parts of the eye, was p. appl. to observe. The irritation index is 40. According to this, 3-mercapto-1,2,4-triazole has moderately irritating properties in the rabbit eye. Systemic-toxic effects did not occur after conjunctival application of the test product. The general condition of the experimental animals was undisturbed.
- Executive summary:
The substance was tested for its eye-irritating properties on rabbits.0.1 g was placed in the conjunctival sac of 3 experimental animals. Observed changes: Cornea: Slight opacity or turbidity, in which details of the iris were slightly shadowed, affected the entire corneal area. Iris: moderate circulatory corneal hyperemia. Conjunctiva: diffuse flesh-colored redness;clear Swelling, which led to the partial turning of the lids or to the half-closed lids. Other eye changes: Hypersecretion, which moistened the surrounding eyelids and hair or considerable parts around the eye. These findings were no longer than 2 weeks p.appl.demonstrated. The determined stimulus index 40. For 3-mercapto-1, 2, 4-triazole, this results in moderately irritating properties in the rabbit eye. Systemic-toxic effects were not detectable.
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