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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010
Report date:
2010

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Principles of method if other than guideline:
The dosing volume was limited to 0.4 mL due to the volatility of the test substance.
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
471-480-0
EC Name:
-
Cas Number:
1645-83-6
Molecular formula:
Hill formula: C3H2F4 CAS formula: C3H2F4
IUPAC Name:
(1E)-1,3,3,3-tetrafluoroprop-1-ene

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Covance Research Products, Inc (Denver, CO)
- Age at study initiation:
- Weight at study initiation: 2.7 - 2.9 kg
- Housing:individually in suspended cages with paper bedding beneath the cages
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 5 days


ENVIRONMENTAL CONDITIONS
- Temperature controlled
- Humidity controlled
- Photoperiod (hrs dark / hrs light): 12 hrs/12 hrs

Test system

Type of coverage:
semiocclusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
not required
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.4 mL
Duration of treatment / exposure:
60 sec, 3 minutes, 4 hours
Observation period:
72 hours post exposure
Number of animals:
3
Details on study design:
TEST SITE
- Area of exposure: 25 mm (Hill top chamber)
- Type of wrap if used: porous dressing large enough to cover the dose site with at least 5 cm square on all sides. Wrap kept in place with non-irritating tape encircling the animal

REMOVAL OF TEST SUBSTANCE
- Washing : not needed

SCORING SYSTEM: Draize

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal: #1, #2, #3
Time point:
24/48/72 h
Score:
0
Max. score:
4
Remarks on result:
no indication of irritation
Irritation parameter:
edema score
Basis:
animal: #1, #2, #3
Time point:
24/48/72 h
Score:
0
Max. score:
4
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
HFO-1234ze was not irritating to rabbit skin
Other effects:
No other effects observed

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
HFO-1234ze is not irritating to rabbit skin following 60 sec, 3 minute, or 4 hours of exposure.
Executive summary:

In a skin irritation study performed in accordance with GLP and OECD guideline 404 three New Zealand White rabbits were exposed semi-occlusive to the test substance. The test substance was found not to be irritating to rabbit skin following 60 sec, 3 minute, or 4 hours of exposure.