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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 2008-10-14 to 2008-11-10
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- other: image analysis
- Type of particle tested:
- primary particle
- Type of distribution:
- mass based distribution
- Specific details on test material used for the study:
- - Analytical purity: > 95.0%
- Lot/batch No.: 2008-9-16 - No.:
- #1
- Size:
- > 105 µm
- Distribution:
- 11.8 %
- No.:
- #2
- Size:
- > 60 - <= 105 µm
- Distribution:
- 18.3 %
- No.:
- #3
- Size:
- > 30 - <= 60 µm
- Distribution:
- 13.2 %
- No.:
- #4
- Size:
- > 10.4 - <= 30 µm
- Distribution:
- 8.8 %
- No.:
- #5
- Size:
- > 0.5 - <= 10.4 µm
- Distribution:
- 2.5 %
- Conclusions:
- The results indicated that 2.5% w/w of test item was smaller than 10 µm.
- Executive summary:
Particle size was determined in accordance with OECD Guideline 110. The particle size distribution was initially examined using sieve analysis. As greater than 10% by weight of the test substance was found to pass a 75 micron sieve, it was further examined by image analysis.
The results indicated that 2.5% w/w of test item was smaller than 10 µm.
Reference
Sieve Analysis
A portion (10 g) of the test substance was weighed into the coarsest of a nest of sieves (100 mm diameter) of aperture sizes 400, 125, 75, 30 and 10 microns. The nest was shaken for 30 minutes with tapping (Pascall Inclyno sieve shaker), and the proportion of the test material passing through each sieve determined gravimetrically. The test was performed in duplicate, and the results are summarised thus:
Particle Size (µm) |
% in range by weight |
||
Test 1 |
Test 2 |
Test 3 |
|
> 400 |
3.5 |
3.4 |
3.5 |
400 – 125 |
40.7 |
40.7 |
40.7 |
125 – 75 |
17.7 |
17.5 |
17.6 |
75 – 30 |
33.6 |
30.1 |
31.9 |
30 – 10 |
3.9 |
7.2 |
5.6 |
< 10 |
0.0 |
0.0 |
0.0 |
Image Analysis (based on BS3406, Part 4, 1993)
A suitable suspending medium was experimentally determined to fulfill the following properties.
i) low solubility
ii) different refractive index
iii) low volatility
iv) good dispersion
Six replicate samples, each approximately 5 g in weight, were individually weighed into a 125 micron sieve and the contents sieved by shaking for 10 minutes. The proportion of each sample passing through the sieve was determined gravimetrically. A portion of the sieved material was suspended by agitation and mounted on a microscope slide for image analysis.
Particle size (µm) |
% Mass |
||||||
Test 1 |
Test 2 |
Test 3 |
Test 4 |
Test 5 |
Test 6 |
Mean |
|
> 125 (sieved) |
46.3 |
45.5 |
44.9 |
45.2 |
45.2 |
45.9 |
45.5 |
> 105 |
8.1 |
16.7 |
12.2 |
6.6 |
17.1 |
10.1 |
11.8 |
60.0 – 105 |
22.6 |
16.7 |
20.0 |
22.8 |
11.4 |
16.3 |
18.3 |
30.0 – 60.0 |
14.5 |
13.3 |
13.0 |
11.7 |
10.8 |
15.8 |
13.2 |
10.4 – 30.0 |
6.9 |
6.2 |
7.7 |
11.3 |
11.1 |
9.4 |
8.8 |
0.5 – 10.4 |
1.7 |
1.6 |
2.2 |
2.3 |
4.5 |
2.5 |
2.5 |
The observed particles were irregular and crystalline in nature.
Description of key information
Particle size was determined in accordance with OECD Guideline 110.
The results indicated that 2.5% w/w of test item was smaller than 10 µm.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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