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EC number: 946-448-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented study report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 987
Materials and methods
- Principles of method if other than guideline:
- Method: other: according to Haworth et al., Environ. Mutagen., 5 (Suppl. 1), 3-142
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 1-aminopropan-2-ol
- EC Number:
- 201-162-7
- EC Name:
- 1-aminopropan-2-ol
- Cas Number:
- 78-96-6
- Molecular formula:
- C3H9NO
- IUPAC Name:
- 1-aminopropan-2-ol
- Details on test material:
- - Name of test material (as cited in study report): Mono-isopropanolamine
- Analytical purity: 96.4%
- Supplier: Aldrich
Constituent 1
Method
- Target gene:
- Strain Target Gene:
TA1537 hisC3076
TA1535 hisG46
TA100 hisG46
TA98 hisD3052
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Metabolic activation system:
- The S9 fractions were prepared from the liver of Aroclor 1254-induced male Sprague-Dawley rats and male Syrian hamsters.
- Test concentrations with justification for top dose:
- 33 - 4000 ug/plate
- Vehicle / solvent:
- water
Controls
- Untreated negative controls:
- not specified
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- not specified
- Positive controls:
- yes
- Positive control substance:
- other: see remarks
- Remarks:
- For strains tested in the absence of S9: TA98, 2-nitrofluorene, TA100 and TA1535, sodium azide, TA1537, 9-aminoacridine. For strains tested with S9: All strains, 2-aminoanthracene.
- Details on test system and experimental conditions:
- METHOD OF APPLICATION: preincubation
DURATION
- Preincubation period: 20 min
- Exposure duration: 2 days
DURATION
- Preincubation period: 20 min
- Exposure duration: 48 h - Evaluation criteria:
- According to Haworth et al. (1983).
Results and discussion
Test resultsopen allclose all
- Species / strain:
- S. typhimurium, other: TA98, TA100, TA1537
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- Slightly toxic at highest dose in the 3 strains.
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- valid
- Species / strain:
- S. typhimurium TA 1535
- Metabolic activation:
- without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- Slightly toxic at highest dose
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- valid
- Species / strain:
- S. typhimurium TA 1535
- Metabolic activation:
- with
- Genotoxicity:
- ambiguous
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- Slightly toxic at highest dose
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- valid
Any other information on results incl. tables
Strain TA100
Dose |
No Activation |
10% HLI |
10% RLI |
|||
Dose units |
Mean |
± SEM |
Mean |
± SEM |
Mean |
± SEM |
0 |
135 |
2 |
141 |
6.8 |
139 |
5.6 |
33 |
152 |
4 |
144 |
8.7 |
132 |
14.4 |
100 |
141 |
3.8 |
140 |
12.2 |
138 |
5.8 |
333 |
148 |
4.2 |
140 |
5.5 |
149 |
11.1 |
1000 |
155 |
0.9 |
128 |
6.4 |
124 |
4.3 |
3333 |
130S |
7.8 |
159S |
7 |
156S |
6.5 |
Positive Control |
1298 |
63.2 |
1452 |
83.5 |
947 |
33.3 |
Strain TA98
Dose |
No Activation |
10% HLI |
10% RLI |
|||
Dose units |
Mean |
± SEM |
Mean |
± SEM |
Mean |
± SEM |
0 |
18 |
2 |
30 |
0.6 |
24 |
1.2 |
33 |
19 |
2.6 |
36 |
1.5 |
25 |
4.4 |
100 |
25 |
2.9 |
43 |
1.9 |
30 |
6.3 |
333 |
17 |
2.3 |
25 |
2.1 |
33 |
0.7 |
1000 |
21 |
3.3 |
31 |
4.5 |
26 |
4.1 |
3333 |
8T |
3.5 |
20S |
4.3 |
20S |
1.8 |
Positive Control |
1475 |
103.9 |
935 |
33.9 |
637 |
42.8 |
Strain TA1537
Dose |
No Activation |
10% HLI |
10% RLI |
|||
Dose units |
Mean |
± SEM |
Mean |
± SEM |
Mean |
± SEM |
0 |
8 |
1.7 |
10 |
1.7 |
8 |
0.9 |
33 |
7 |
2.9 |
12 |
1.5 |
11 |
2.9 |
100 |
7 |
0.3 |
13 |
1.7 |
9 |
0.9 |
333 |
6 |
1.8 |
7 |
1.2 |
7 |
1 |
1000 |
6 |
0.6 |
7 |
1.3 |
8 |
0.3 |
3333 |
4S |
1.2 |
4S |
0.3 |
5S |
0.3 |
Positive Control |
87 |
12.3 |
124 |
6.1 |
97 |
2.9 |
Strain TA1535:
Dose |
No Activation |
No Activation |
No Activation |
No Activation |
10% HLI |
10% HLI |
10% HLI |
10% HLI |
10% RLI |
10% RLI |
10% RLI |
10% RLI |
||||||||||||
Dose units |
Mean |
± SEM |
Mean |
± SEM |
Mean |
± SEM |
Mean |
± SEM |
Mean |
± SEM |
Mean |
± SEM |
Mean |
± SEM |
Mean |
± SEM |
Mean |
± SEM |
Mean |
± SEM |
Mean |
± SEM |
Mean |
± SEM |
0 |
27 |
5 |
54 |
6.4 |
7 |
1.2 |
36 |
3.6 |
9 |
0.9 |
11 |
3.2 |
9 |
2.5 |
5 |
1 |
9 |
1.5 |
9 |
0.7 |
7 |
1.5 |
11 |
0 |
33 |
30 |
1.5 |
|
|
|
|
|
|
11 |
2.2 |
|
|
|
|
|
|
7 |
2.6 |
|
|
|
|
|
|
100 |
30 |
4.4 |
51 |
4.2 |
7 |
0.9 |
34 |
0.9 |
11 |
1 |
9 |
1 |
8 |
1.2 |
10 |
2.3 |
11 |
1.2 |
10 |
0.6 |
7 |
1.9 |
11 |
1.3 |
333 |
27 |
4.4 |
45 |
2.2 |
6 |
1.5 |
32 |
5 |
14 |
0.9 |
14 |
1.2 |
6 |
0.7 |
11 |
2 |
9 |
0.9 |
14 |
2.8 |
6 |
0.7 |
7 |
0.3 |
1000 |
20 |
1.5 |
47 |
3.8 |
4 |
0.7 |
23 |
4.8 |
10 |
1.2 |
9 |
0.3 |
7 |
1.3 |
11 |
4.2 |
7 |
1.8 |
14 |
0.7 |
5 |
1.5 |
9 |
0.7 |
1800 |
|
|
34 |
3.8 |
5 |
1.3 |
28 |
1.3 |
|
|
24 |
1.9 |
10 |
1.3 |
29 |
0.7 |
|
|
15 |
1.9 |
5 |
1.7 |
13 |
3.2 |
2800 |
|
|
25S |
0.9 |
4S |
1 |
23S |
2 |
|
|
30S |
2.9 |
5 |
0.6 |
28 |
6.6 |
|
|
33S |
4.3 |
8 |
2 |
32 |
2.1 |
3333 |
12S |
3.8 |
25S |
4.5 |
4S |
0.9 |
16S |
3.2 |
27S |
1.7 |
20S |
1.8 |
8S |
2.1 |
24S |
2.7 |
17S |
2.5 |
32S |
2.6 |
6S |
2.2 |
32S |
2.2 |
3500 |
|
|
16S |
0.6 |
3S |
0.6 |
21S |
0.3 |
|
|
18S |
2.7 |
6S |
1.5 |
25S |
4.7 |
|
|
20S |
1.5 |
6S |
1 |
26S |
2.2 |
4000 |
|
|
13S |
1.7 |
2S |
0.6 |
17S |
2.1 |
|
|
21S |
0.9 |
3S |
0.3 |
15S |
2.4 |
|
|
26S |
5.1 |
4S |
1.7 |
23S |
3.3 |
Positive Control |
1005 |
61 |
1484 |
111 |
869 |
23.8 |
1124 |
41.3 |
124 |
3.5 |
99 |
2.3 |
85 |
2.3 |
231 |
16.1 |
98 |
6.4 |
95 |
11.4 |
83 |
4.7 |
103 |
13.6 |
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; T = Toxic; c = Contamination
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results: ambiguous with metabolic activation
Under the conditions tested the test substance was not mutagenic in the strains TA98, TA100 and TA1537.
However, with S9-activation the TA1535 strain presented some weak positive results. Therefore the test substance was rated as ambiguous.
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