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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- GLP compliance:
- yes (incl. QA statement)
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- Duplicate sample solutions were taken initially and from the waterbath at various time points. The pH of each solution was recorded. The concentration of test item in the sample solutions was determined by high performance liquid chromatography (HPLC).
Samples
An aliquot of the pH 4 and 7 sample solutions were basified with drops of triethylamine to improve their peak shape. An aliquot of the pH 9 sample solution was analysed without further treatment. - Buffers:
- The test system consisted of a pH 4 buffer solution and purified water which was adjusted to pH 7 and 9 after addition of the test item.
- Duration:
- 24 h
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 193 mg/L
- Duration:
- 120 h
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 193 mg/L
- Duration:
- 24 h
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 211 mg/L
- Duration:
- 24 h
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 209 mg/L
- Duration:
- 120 h
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 211 mg/L
- Duration:
- 120 h
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 209 mg/L
- Duration:
- 24 h
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 222 mg/L
- Duration:
- 24 h
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 220 mg/L
- Duration:
- 120 h
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 222 mg/L
- Duration:
- 120 h
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 220 mg/L
- Duration:
- 670 h
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 222 mg/L
- Duration:
- 670 h
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 220 mg/L
- Number of replicates:
- 2
- Positive controls:
- no
- Negative controls:
- no
- Transformation products:
- not measured
- Details on hydrolysis and appearance of transformation product(s):
- Due to additional peaks forming in the chromatography when the test was performed with pH 7 and pH 9 buffers, the test was repeated with the stock solutions being prepared in purified water followed by pH adjustment. Although the pH 7 samples maintained the required pH (± 0.1), the pH 9 samples did drop to approximately pH 8.5 for the 477¼ and 670 Hours’ time points. This was possibly a consequence of the reaction of the test item over time. It was considered that this did not have a significant effect on the test as the rate of hydrolysis was not calculated. Significant changes in pH would probably affect the hydrolytic rate as the pH drifts. In contrast, the pH 4 buffer did not form significant additional peaks in the chromatography and was therefore used in the test.
The samples and standards were prepared in plastic vessels because the test item readily absorbed to the surface of glass vessels, including after silanizing the glass.
The addition of triethylamine to the pH 4 and pH 7 samples was to basify them and improve the peak shape as they had a tendency to tail/broaden. This was successful for pH 7 but not completely so for pH 4. In contrast, the standards being prepared in just purified water were already basic due to the test item.
No significant peaks were observed at the approximate retention time of the test item on analysis of the matrix blank solution. Therefore blank subtraction was not performed.
From the result it can be clearly seen that the concentration at pH 9 decreases over time. However the decrease is not linear as would usually be expected for hydrolysis as water is always in significant excess and isn’t a rate limiting step. Additionally, the main components of the test item had no functional groups that were expected to hydrolyse under conditions of the test. Oxidation with dissolved oxygen is a possibility, but this would be expected to be too low in concentration to be responsible for the decrease in concentration of the test item. Reaction with itself could be possible but this was not confirmed. - % Recovery:
- 100
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 24 h
- % Recovery:
- 95.8
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 120 h
- % Recovery:
- 99.1
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 24 h
- % Recovery:
- 98.1
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 120 h
- % Recovery:
- 89.7
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 24 h
- % Recovery:
- 79.7
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 120 h
- % Recovery:
- 65.7
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 477.25 h
- % Recovery:
- 62.3
- pH:
- 9
- Temp.:
- 50 °C
- Duration:
- 670 h
- pH:
- 4
- Temp.:
- 50 °C
- DT50:
- > 1 yr
- Type:
- not specified
- pH:
- 7
- Temp.:
- 50 °C
- DT50:
- > 1 yr
- Type:
- not specified
- pH:
- 9
- Temp.:
- 50 °C
- Remarks on result:
- not determinable
- Validity criteria fulfilled:
- yes
- Conclusions:
- The estimated half-life at 25 °C of the test item has been shown to be greater than 1 year at pH 4 and 7. For pH 9, 38% was lost in 28 days at 50 °C; however, it was considered that although the concentration of test item reduced over time it was most probably not due to hydrolysis.
- Executive summary:
The estimated half-life at 25 °C of the test item has been shown to be greater than 1 year at pH 4 and 7. For pH 9, 38% was lost in 28 days at 50 °C; however, it was considered that although the concentration of test item reduced over time it was most probably not due to hydrolysis.
Reference
Description of key information
The estimated half-life at 25 °C of the test item has been shown to be greater than 1 year at pH 4 and 7. For pH 9, 38% was lost in 28 days at 50 °C; however, it was considered that although the concentration of test item reduced over time it was most probably not due to hydrolysis.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 yr
- at the temperature of:
- 50 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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