Registration Dossier
Registration Dossier
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EC number: 231-588-9 | CAS number: 7646-78-8
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 002
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 984
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 413 (Subchronic Inhalation Toxicity: 90-Day Study)
- Deviations:
- not applicable
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- Hydrogen chloride
- EC Number:
- 231-595-7
- EC Name:
- Hydrogen chloride
- Cas Number:
- 7647-01-0
- Molecular formula:
- ClH
- IUPAC Name:
- chloride
- Test material form:
- gas
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD(SD)Br
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: gas
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- yes
Doses / concentrationsopen allclose all
- Dose / conc.:
- 0 ppm
- Dose / conc.:
- 10 ppm
- Dose / conc.:
- 20 ppm
- Dose / conc.:
- 50 ppm
- Control animals:
- yes
Results and discussion
Results of examinations
- Clinical signs:
- not specified
- Description (incidence and severity):
- -
- Mortality:
- no mortality observed
- Description (incidence):
- -
- Body weight and weight changes:
- effects observed, treatment-related
- Description (incidence and severity):
- -
- Food consumption and compound intake (if feeding study):
- effects observed, treatment-related
- Description (incidence and severity):
- -
- Food efficiency:
- not specified
- Description (incidence and severity):
- -
- Water consumption and compound intake (if drinking water study):
- not examined
- Description (incidence and severity):
- -
- Ophthalmological findings:
- not examined
- Description (incidence and severity):
- -
- Haematological findings:
- not specified
- Description (incidence and severity):
- -
- Clinical biochemistry findings:
- not specified
- Description (incidence and severity):
- -
- Urinalysis findings:
- not specified
- Description (incidence and severity):
- -
- Behaviour (functional findings):
- not specified
- Description (incidence and severity):
- -
- Immunological findings:
- not specified
- Description (incidence and severity):
- -
- Organ weight findings including organ / body weight ratios:
- effects observed, treatment-related
- Description (incidence and severity):
- -
- Gross pathological findings:
- effects observed, treatment-related
- Description (incidence and severity):
- -
- Neuropathological findings:
- no effects observed
- Description (incidence and severity):
- -
- Histopathological findings: non-neoplastic:
- effects observed, treatment-related
- Description (incidence and severity):
- As histopathologically inflammatory changes were observed above 20 ppm, NOAEL was determined to be 10 ppm
- Histopathological findings: neoplastic:
- no effects observed
- Description (incidence and severity):
- -
- Other effects:
- not examined
- Description (incidence and severity):
- -
- Details on results:
- -
Effect levels
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- 10 ppm
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- histopathology: non-neoplastic
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- As histopathologically inflammatory changes were observed above 20 ppm, NOAEL was determined to be 10 ppm.
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