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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- GLP compliance:
- yes
- Details on sampling:
- An aliquot of samples was transferred to a 2 mL auto-sampler vial and analyzed by GC-FID. The each samples was immeidately analyzed after pretreatment of samples. The pH values of each sample were measured and recorded at each sampling time.
- Buffers:
- pH 4.0: 4.0 mL of 0.1 N NaOH and 500 mL of 0.1 M potassium biphthalate were added to water and made up to 1000 mL
pH 7.0: 296.3 mL of 0.1 N NaOH and 500 mL of 0.1 M monopotassium phosphate were added to water and made up to 1000 mL
pH 9.0: 213.0 mL of 0.1 N NaOH and 500 mL of 0.1 M boric acid in 0.1 M KCl were added to water and made up to 1000 mL - Estimation method (if used):
- Hydrolysis rate constant (Kobs) was calculated by assuming first-order kinetic according to the following equation;
Kobs = 1/t ln(C0/Ct)
The degradation rate half-life was calculated as follows.
t1/2 (half-life) = 0.693/Kobs
t = time
C0 = concentration at time 0
Kobs = first-order bydrolysis rate constant - Duration:
- 5 d
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- ca. 67.5 mg/L
- Remarks:
- (Tier I) constitiuent-1
- Duration:
- 5 d
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- ca. 38 mg/L
- Remarks:
- (Tier I) constitiuent-2
- Duration:
- 5 d
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- ca. 386 mg/L
- Remarks:
- (Tier I) constitiuent-3
- Duration:
- 5 d
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- ca. 67.5 mg/L
- Remarks:
- (Tier I) constitiuent-1
- Duration:
- 5 d
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- ca. 38 mg/L
- Remarks:
- (Tier I) constitiuent-2
- Duration:
- 5 d
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- ca. 386 mg/L
- Remarks:
- (Tier I) constitiuent-3
- Duration:
- 5 d
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- ca. 67.5 mg/L
- Remarks:
- (Tier I) constituent-1
- Duration:
- 5 d
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- ca. 38 mg/L
- Remarks:
- (Tier I) constituent-2
- Duration:
- 5 d
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- ca. 386 mg/L
- Remarks:
- (Tier I) constituent-3
- Duration:
- 30 d
- pH:
- 9
- Temp.:
- 15 °C
- Initial conc. measured:
- ca. 68 mg/L
- Remarks:
- (Tier II) composition_1
- Duration:
- 30 d
- pH:
- 9
- Temp.:
- 15 °C
- Initial conc. measured:
- ca. 375.5 mg/L
- Remarks:
- (Tier II) composition_3
- Duration:
- 30 d
- pH:
- 9
- Temp.:
- 25 °C
- Initial conc. measured:
- ca. 68 mg/L
- Remarks:
- (Tier II) composition_1
- Duration:
- 30 d
- pH:
- 9
- Temp.:
- 25 °C
- Initial conc. measured:
- ca. 375.5 mg/L
- Remarks:
- (Tier II) composition_3
- Duration:
- 30 d
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- ca. 68 mg/L
- Remarks:
- (Tier II) composition_1
- Duration:
- 30 d
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- ca. 375.5 mg/L
- Remarks:
- (Tier II) composition_3
- Number of replicates:
- hydrolysis test: duplicate
recovery test: triplicate - Positive controls:
- no
- Negative controls:
- no
- Preliminary study:
- At the prelimanary test (Tier I) which was incubated at 50˚С for up to 5 days, the hydrolysis rates of the 'constituent_1' were .3, 8.9, and 44.7%, 'constituent_2' was 8.0, 7.9, and 5.6% and the 'compostion_3' was negative value (-1.9, -1.8, -222.1%) at sterile aqueous solutions of pH 4.0, 7.0 and 9.0, respectively.
The results showed that the 'constituent_2' was hydrolytically stable (less than 10% of hydrolysis) at pH 4.0, 7.0 and 9.0. However, the 'constituent_1' and 'constituent_3' were only stable at pH 4.0 and 7.0 because their concentrations increased ('constituent-1') or decreased ('constituent-3) at pH 9.0. Therefore, only 'constituent-1' and 'contsitutent-3' were observed at pH 9.0 solution of Tier II. - Test performance:
- At hydrolysis test (Tier II) which was incubated at 15, 25 and 50˚С in sterile buffer solutions of pH 9.0, 'constituent_1' and 'constituent_3' were calculated.
The identification of hydrolysis products (Tier III) could not be performed because of lack of information and authentic reference for hydrolysis products. - Transformation products:
- yes
- No.:
- #1
- Details on hydrolysis and appearance of transformation product(s):
- The ‘constituent_3’ increased gradually and rapidly depending on test temperature, while the constituent_1’ showed a tendency of decreasing values at pH 9.0,
indicating that the ‘constituent_1’ was hydrolytically degraded into the ‘constituent_3’. - % Recovery:
- ca. 55.7
- pH:
- 4
- Remarks on result:
- other:
- Remarks:
- constituent_3
- % Recovery:
- ca. 59.3
- pH:
- 7
- Remarks on result:
- other:
- Remarks:
- constituent_3
- % Recovery:
- ca. 57.7
- pH:
- 9
- Remarks on result:
- other:
- Remarks:
- constituent_3
- % Recovery:
- ca. 120.3
- pH:
- 4
- Remarks on result:
- other:
- Remarks:
- compostion_2
- % Recovery:
- ca. 122.2
- pH:
- 7
- Remarks on result:
- other:
- Remarks:
- compostion_2
- % Recovery:
- ca. 119.9
- pH:
- 9
- Remarks on result:
- other:
- Remarks:
- compostion_2
- % Recovery:
- ca. 120.7
- pH:
- 4
- Remarks on result:
- other:
- Remarks:
- constituent_1
- % Recovery:
- ca. 122.1
- pH:
- 7
- Remarks on result:
- other:
- Remarks:
- constituent_1
- % Recovery:
- ca. 119.7
- pH:
- 9
- Remarks on result:
- other:
- Remarks:
- constituent_1
- pH:
- 9
- Temp.:
- 15 °C
- Hydrolysis rate constant:
- ca. 0.009 d-1
- DT50:
- ca. 77 d
- St. dev.:
- 0.662
- Type:
- (pseudo-)first order (= half-life)
- Key result
- pH:
- 9
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- ca. 0.013 d-1
- DT50:
- ca. 52.3 d
- St. dev.:
- 0.832
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 9
- Temp.:
- 50 °C
- Hydrolysis rate constant:
- ca. 0.086 d-1
- DT50:
- ca. 8.1 d
- St. dev.:
- 0.977
- Type:
- (pseudo-)first order (= half-life)
- Conclusions:
- The test substance was determined stable in aqueous buffer solutions of pH 4, 7, but among composition, the 'constituent_1' was unstable at pH 9. Therefore, the test substance was considered it would be more hydrolyzed readily in alkaline condition than in neutral and acid conditions. In addition, the 'constituent_1' contained in the test substance was transformed into the 'constituent_3' in the hydrolysis test.
Reference
Description of key information
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 52.3 d
- at the temperature of:
- 25 °C
Additional information
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